نتایج جستجو برای: 4 3h quinazolinones
تعداد نتایج: 1317057 فیلتر نتایج به سال:
To understand the signaling and growth-inhibitory effects of retinoids, we have examined the metabolism of [3H]retinol in a number of estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) human breast cancer cell lines. We have also assayed the metabolism of [3H]retinol in normal human mammary epithelial cells. The ER+ breast cancer cell lines MCF-7 and T47D produce [3H]4-oxoret...
In the title compound, C(18)H(15)NO(3), the pyridine-2,6-dione ring adopts an envelope conformation. The phenyl ring lies approximately perpendicular to the mean plane of the pyridine-2,6-dione ring [dihedral angle = 81.5 (1)°], while the methoxy-phenyl ring is tilted to the same plane by a dihedral angle of 34.8 (1)°. Inter-molecular C-H⋯O inter-actions link the mol-ecules into chains along [1...
Nitration of phenol and various 4-substituted phenols with Cu(NO3)2.3H2O, Cu(NO3)2.3H2O/SiO2, 9H2O and Cr(NO3)2. 9H2O in different anhydrous organic solvents are investigated. High selectivity ratio of para vs ortho isomers has been observed. Mono- and dinitro compounds f...
• GPR120 (short isoform) homology model used for docking-based virtual screening (DBVS) of ligand database. Combination approach in silico and vitro to discover potential anti-cancer compounds targeting GPR120. Identification a dihydrospiro(benzo[ h ]quinazoline-5,1?-cyclopentane)-4(3H)-one scaffold activity. The G-protein coupled receptor - has recently been implicated as novel target colorect...
The novel compound 2-{[4-(4-bromophenyl)piperazin-1-yl)]methyl}-4-(3-chlorophenyl-5-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione is obtained in good yield via a three-step protocol. product’s structure assigned by HRMS, IR, 1H and 13C NMR experiments.
In the asymmetric unit of the title compound, C(9)H(8)N(2)S, there are four symmetry-independent mol-ecules (Z' = 4). The geometrical features of these mol-ecules are quite similar: in the normal probability plots the R(2) correlation factors for bond lengths and angles are generally around 0.95. The twist angles between the imidazole and phenyl rings (which are planar within 3σ) range from 9.0...
The crystal structure of the title compound, C(12)H(11)NS, features parallel chains of alternating N-H⋯S hydrogen-bonded mirror-image conformers along [10[Formula: see text]]. The mol-ecular conformation is that of an envelope, with all of the framework atoms except one close to a mean plane (rms deviation 0.054 Å); one C atom of the cyclo-hexene-thione ring forms the envelope flap, which makes...
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