Mutations of the KRAS proto-oncogene are associated with several tumor types, which is why it is being considered as a target for anti-cancer drug development. The human KRAS promoter contains a nuclease hypersensitive element (NHE), which can bind to nuclear proteins and is believed to form G-quadruplex structures. Previous studies showed that a 32-nt oligonucleotide (32R-3n) mimicking the KRA...

The new neutron-deficient isotope $^{249}$No was synthesized for the first time in fusion-evaporation reaction $^{204}$Pb($^{48}$Ca,3n)$^{249}$No. After separation, using kinematic separator SHELS, identified with GABRIELA detection system through genetic correlations known daughter and granddaughter nuclei $^{245}$Fm $^{241}$Cf. alpha-decay activity of has an energy 9129(22)$~$keV half-life 38...

The objective of this study was to determine the effects of feeding an increased amount of extruded flaxseed with high proportions of n-3 fatty acids (FA) to transition dairy cows on performance, energy balance, and FA composition in plasma, adipose tissue, and milk fat. Multiparous Israeli-Holstein dry cows (n = 44) at 256 d of pregnancy were assigned to 2 treatments: (1) control cows were fed...

C is an (n,M, d)q code over Fq of length n with M codewords and minimum distance d. The code C can be either linear or nonlinear. A t − (v, k, λ) design D is a set X of v points together with a collection of k−subsets of X (called block) such that every t−subset of X is contained in exactly λ blocks. In this paper a new binary code ( n−1 2 , 3n−1 2 , 2.3 n−2), n ≥ 3 is developed. Some propertie...

The group of local unitary transformations acts on the space of n-qubit pure states, decomposing it into orbits. In a previous paper we proved that a product of singlet states (together with an unentangled qubit for a system with an odd number of qubits) achieves the smallest possible orbit dimension, equal to 3n/2 for n even and (3n+ 1)/2 for n odd, where n is the number of qubits. In this pap...