Random Positioning Machines (RPMs) have been used since many years as a ground-based model to simulate microgravity. In this review we discuss several aspects of the RPM. Recent technological development has expanded the operative range of the RPM substantially. New possibilities of live cell imaging and partial gravity simulations, for example, are of particular interest. For obtaining valuabl...

Tissue engineering of chondrocytes on a Random Positioning Machine (RPM) is a new strategy for cartilage regeneration. Using a three-dimensional RPM, a device designed to simulate microgravity on Earth, we investigated the early effects of RPM exposure on human chondrocytes of six different donors after 30 min, 2 h, 4 h, 16 h, and 24 h and compared the results with the corresponding static cont...

Synapses display a stereotyped ultrastructural organization, commonly containing a single electron-dense presynaptic density surrounded by a cluster of synaptic vesicles. The mechanism controlling subsynaptic proportion is not understood. Loss of function in the C. elegans rpm-1 gene, a putative RING finger/E3 ubiquitin ligase, causes disorganized presynaptic cytoarchitecture. RPM-1 is localize...

OBJECTIVE To examine the association between consumption of red and processed meat (RPM) and iron intakes and status in adults. DESIGN Further analysis of the Dietary and Nutritional Survey of British Adults, a cross-sectional study of 2197 adults aged 16-64 years carried out in 1986/7. SUBJECTS AND METHODS Adults (836 men and 838 women) with serum ferritin measurements, who were not taking...

Copper promotion of chromium-doped iron oxide prepared via co-precipitation for high-temperature water–gas shift (WGS) catalysis is investigated. Low-temperature Mössbauer spectra demonstrate that copper doping delays hematite (?-Fe2O3) formation in the fresh catalyst, favoring small crystallites ferrihydrite (Fe5HO8?4 H2O). Catalysts are treated under industrial WGS conditions at 360 °C (activ...

The purpose of this study was to quantify the performance and agreement between two different external surrogate acquisition systems: Varian's Real-Time Position Management (RPM) and Philips Medical Systems' pneumatic bellows, in the context of waveform and 4D CT image analysis. Eight patient displacement curves derived from RPM data were inputted into a motion platform with varying amplitudes ...

Cataract surgery is the most common elective operation performed worldwide (1, 2). The development of new technologies and new surgical techniques and materials lead to less invasive and day care procedures. This in turn encouraged an evolution on the ophthalmic anesthetic strategies, rendering general anesthesia largely unnecessary, so that local techniques have become preferred for cataract s...

Sao Paulo Med J. 2007;125(2):85-90. O R IG IN A L A R T IC L E Oscar Tadashi Matsuoka

Xbox Live Achievements and Gamerscores have become an important part of Xbox 360 gaming and have played an important role in the success of the console. Based on the framework provided by Microsoft, the community has created a rich and intriguing meta-game where the individual games become pieces of a larger whole. For every game released on the system, the developer has to define a number of a...