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Ce travail repose sur l’écoute des œuvres et interroge la notion d’interprétation selon un croisement de trois paradigmes : musicologie, psychanalyse philosophie. Pour orienter notre jugement l’interprétation, du réel dans l’œuvre représente repère qui se distingue sublime, cette sera définie d’un point vue psychana...
Epitope specificity and isotype influence mAb efficacy against Cryptococcus neoformans; however, the relative contribution of each attribute is poorly understood. To date, only mAbs that recognize two epitopes of capsular glucuronoxylomannan (GXM), defined by the IgG1 mAbs 2H1 and E1, consistently mediate protection against C. neoformans. The role of epitope specificity was further examined usi...
GX 339–4 is an unusual black hole candidate in that it is a persistent source, being detected by X-ray telescopes most of the time, but it also has nova-like flaring states. In 1996 we performed radio, optical, X-ray, and gamma-ray observations of GX 339–4 when it was in a hard state (= soft X-ray low state). Here we present a brief summary of some of the results. At this time, neither the ASM ...
D-Glucarate dehydratase from Escherichia coli (GlucD), a member of the enolase superfamily, catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (KDG). Previous mutagenesis and structural studies identified Lys 207 and the His 339-Asp 313 dyad as the general basic catalysts that abstract the C5 proton from L-idarate and D-glucarate, respectively, thereb...
The chemokine receptor CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. Upon stimulation by the endogenous ligand CXCL12, CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain. Mutations in the CXCR4 gene affecting C-terminal phosphorylation sites are a hallmark of WHIM syndrome, a genetic disorder characterized by a gain-...
BACKGROUND AND PURPOSE The use of stents for treatment of morphologically unfavorable, acutely ruptured aneurysms is avoided by most operators because of concerns about the risk of using dual antiplatelet therapy in the setting of acute SAH. Our aim was to review the literature regarding stent-assisted coil embolization of acutely ruptured intracranial aneurysms to determine the safety and effi...
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