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Selenium is used extensively in many industries, and it is necessary for human nutrition. On the other hand, it is also toxic at slightly elevated concentrations. With the advent of industrialisation, selenium concentrations in the environment due to anthropogenic activities have increased. Treatment of selenium-laden wastewaters and bioremediation are of increasing importance for counteracting...
This article is part of a Minifocus on invadopodia and podosomes. For further reading, please see related articles: ‘Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia’ by Renaud Poincloux et al. (J. Cell Sci. 122, 3015-3024), ‘Mechanisms for transcellular diapedesis: probing and pathfinding by ‘invadosome-like protrusions’’ by Christopher V. Carman (J. Cell Sci. 122...
The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors, including vascular endothelial growth factor (VEGF) and insulin-like growth factors (IGFs). Dysregulation of the mTOR pathway has been found in many h...
The northern part of the North Atlantic Craton (NAC) in southern West Greenland comprises a large tract exposed Meso-Neoarchaean continental crust, divided into ca 3300–2900 Ma Akia and 2900–2500 Tuno terranes. We combine aeromagnetic, stream sediment geochemical, new litho-chemical zircon geochronological data with previously published to re-evaluate crustal architecture evolution terrane its ...
Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany; Department of Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK; Scottish National Advanced Heart Fail...
INTRODUCTION Preliminary data suggest that dipeptidyl peptidase-4 (DPP-4) inhibitors may reduce microvascular events, but there is a little evidence to support this from adequate real-world studies. This study aimed to compare microvascular outcomes between patients-prescribed vildagliptin and those prescribed sulfonylurea (SU). METHODS This retrospective cohort study was conducted on a large...
OBJECTIVE We studied the characteristics of patients with ST segment elevation myocardial infarction (STEMI) after expansion of a STEMI registry as part of the STEMI network programme in a metropolitan city and the surrounding area covering ∼26 million inhabitants. DESIGN Retrospective cohort study. SETTING Emergency department of 56 health centres. PARTICIPANTS 3015 patients with acute c...
The determination of cholinesterase (ChE) activity in domestic animals is of great importance for diagnosis and research purposes. The present work was aimed to determine the baseline plasma ChE activities (acetylcholinesterase, AChE and butyrylcholinestarase, BChE) of Argentine saddle horses sampled from equine farms of Bogota (Colombia) and its surroundings. Plasma AChE and BChE catalytic act...
BACKGROUND Body weight scales to height with a power of ≈2, thus forming the basis of body mass index (weight/height(2)). The corresponding scaling of body composition to height has not been established in a representative sample of US adults. OBJECTIVE The aim of the study was to examine the scaling of weight, fat, fat-free mass, and bone mineral content to height. DESIGN Adult non-Hispani...
OBJECTIVE To evaluate the mean changes in Central Corneal Thickness (CCT) and Endothelial Cell Count (ECC) in eyes after pediatric cataract surgery with foldable intraocular lens using scleral tunnel incision micro-surgical technique. STUDY DESIGN Qausi experimental study. PLACE AND DURATION OF STUDY Department of Pediatric Ophthalmology and Strabismus, Al-Shifa Trust Eye Hospital, Rawalpin...
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