SUR2A is an 'atypical' ABC protein that forms sarcolemmal ATP-sensitive K+ (KATP ) channels by binding to inward rectifier Kir6.2. Manipulation with SUR2A levels has been suggested to be a promising therapeutic strategy against ischaemic heart diseases and other diseases where increased heart resistance to stress is beneficial. Some years ago, it has been reported that high-altitude residents h...

Introduction:  All of  the  people worldwide  are exposed  to  low levels  of  radiation. Cancer induction  and  genetic disorders are among the hazards of low level exposure. In some cases, radiation close to hot springs is  higher than normal areas due to a high concentration and the decay products of Ra-226. Given the use of hot  springs by the general public  because  of their therapeutic p...

The flood hazard in New York City depends on both storm surges and rising sea levels. We combine modeled storm surges with probabilistic sea-level rise projections to assess future coastal inundation in New York City from the preindustrial era through 2300 CE. The storm surges are derived from large sets of synthetic tropical cyclones, downscaled from RCP8.5 simulations from three CMIP5 models....

The vertical absolute fluxes of atmospheric muons and muon charge ratio have been measured precisely at different geomagnetic locations by using the BESS spectrometer. The observations had been performed at sea level (30 m above sea level) in Tsukuba, Japan, and at 360 m above sea level in Lynn Lake, Canada. The vertical cutoff rigidities in Tsukuba (36.2◦N ,140.1◦E) and in Lynn Lake (56.5◦N ,1...

The Kingdom of Nepal is a landlocked country bordered by the Tibet, an Autonomous Region of the People's Republic of China in the north and of the Republic of India in all other directions. It o o o is situated between the 26 22'N and 30 27'N latitudes and 80 4'E o and 88 12'E longitudes. Its altitude varies from 80 meters above mean sea level in the southern Terai to 8,848 meters above mean 1 ...

Klyrgyzstan is a rugged country, with the Tien Shan lmountain range covering approximately 95% of the whole territory. The average altitude in Kyrgyzstan is 2,750m above sea level. The highest point is Peak Pobeda at 7,439m and the lowest is 350m above sea level in the south-west of the republic. Kyrgyzstan is the second smallest of the Central Asian republics in both area and population and is...

The Rio Bogotá (Bogota River) descends 370 km through the plain of Bogotá from an altitude of 3400 m above sea level in Villapinzón before it discharges into the Magdalena River at 280 m above sea level (Bravo et al., 1999). The upper river is relatively small and shallow with a limited gradient until, halfway along its route; it passes Bogotá, not only Colombia’s Capital City but also an impor...

Radar altimetry was initially designed to measure the marine geoid. Thanks to the improvement in the orbit determination from the meter to the centimeter level, this technique has been providing accurate measurements of the sea surface topography over the open ocean since the launch of Topex/Poseidon in 1992. In spite of a decrease in the performance over land and coastal areas, it is now commo...