Generalized social phobia (GSP) involves the fear of being negatively evaluated. Previous work suggests that self-referentiality, mediated by the medial prefrontal cortex (MFPC), plays an important role in the disorder. However, it is not clear whether this anomalous MPFC response to self-related information in patients with GSP concerns an increased representation of their own or others' opini...

Aging, a multifactorial process of enormous complexity is characterized by impairment of physio-chemical and biological aspects of cellular functions. It is closely associated with increased free radical production, which situation ultimately leads to devastation of normal cell function and membrane integrity. The present study was aimed to determine the effect of proanthocyanidins rich grape s...

Nonalcoholic fatty liver disease (NAFLD), a premorbid condition, lacks proper management owing to multitude of abnormalities. In this study, we compared the effects of a potent antioxidant, grape seed proanthocyanidins (GSP), and an insulin sensitizer, metformin (MET), in high-fat-fructose-diet- (HFFD-) induced albino Wistar rat model of NAFLD. Either GSP (100 mg/Kg b.w) or MET (50 mg/Kg b.w) o...

Knowledge about grassland biomass and its dynamics is critical for studying regional carbon cycles and for the sustainable use of grassland resources. In this study, we investigated the spatio-temporal variation of biomass in the Xilingol grasslands of northern China. Field-based biomass samples and MODIS time series data sets were used to establish two empirical models based on the relationshi...

Recent studies have witnessed the effectiveness of 3D convolutions on segmenting volumetric medical images. Compared with 2D counterparts, can capture spatial context in three dimensions. Nevertheless, models employing introduce more trainable parameters and are computationally complex, which may lead easily to model overfitting especially for applications limited available training data. This ...

Evidence suggests the existence of a direct relationship between cellular Gsa content and activation of the adenylyl cyclase system. Data on Gsa levels in endocrine tumors that depend on cAMP for growth, particularly pituitary adenomas, are still limited. The levels of Gsa protein were evaluated in 11 GH-secreting adenomas with Gsa mutations (gsp) and 15 without (gsp). Complementary DNAs from g...

Cellular redox conditions affect Gsp amidase activity in Escherichia coli. Guided by the structure and catalytic mechanism of the amidase, we designed and synthesized an acyloxymethyl ketone-based activity probe containing a biotin handle. This probe was used to monitor Gsp amidase activity in E. coli lysates that had been subjected to oxidative or methylglyoxal-induced stress.

Geniculate ganglion (GG) cell bodies of chorda tympani (CT), greater superficial petrosal (GSP), and posterior auricular (PA) nerves transmit orofacial sensory information to the rostral nucleus of the solitary tract (rNST). We used whole cell recording to study the characteristics of the Ca(2+) channels in isolated Fluorogold-labeled GG neurons that innervate different peripheral receptive fie...

Data transaksi penjualan supermarket online merupakan sequence dataset. ini menyimpan data pembelian yang dilakukan oleh pelanggan, sehingga dapat dianalisis menggunakan pendekatan Market Basket Analysis (MBA). Masalah sering dialami pihak adalah sulitnya menerapkan strategi akurat kepada para konsumen. Berdasarkan masalah tersebut, pada penelitian akan analisis terhadap dataset West Superstore...