The hydrogen isotope (2H/1H) ratio of lipids from phytoplankton is a powerful new tool for reconstructing hydroclimate variations in the geologic past from marine and lacustrine sediments. Water 2H/1H changes are reflected in lipid 2H/1H changes with R2 > 0.99, and salinity variations have been shown to cause about a 1‰ change in lipid δ2H values per unit (ppt) change in salinity. Less understo...

Abstract Nonribosomal cyclopeptide cyclosporin A (CsA), produced by fungus Tolypocladium inflatum, is an extremely important immunosuppressive drug used in organ transplantations and for therapy of autoimmune diseases. Here we report the first time production CsA, along with related cyclosporins B C, inflatum strains marine origin (White Sea). Cyclosporins A–C contain unusual amino acid, (4R)-4...

Nitrous acid (HONO) plays pivotal roles in various metal-free as well metal-mediated routes relevant to biogeochemistry, atmospheric chemistry, and mammalian physiology. While the metastable nature of HONO hinders detailed investigations into its reactivity at a transition metal site, this report herein utilizes heteroditopic copper(II) cryptate [oC]CuII featuring proton-responsive second-coord...

High-latitude lakes are sensitive to climate change and store information about large-scale circulation changes catchment-integrated processes. Lakes mainly recharged by meteoric water, meaning that some lake sediment proxies may indirectly archive the stable isotopic composition of hydrogen (?2H) oxygen (?18O) past precipitation. Yet, despite similar precipitation input, within a region exhibi...