Vitamin A and its derivatives, particularly retinol, slow both chronological photo-induced aging processes. Retinol reduces the appearance of wrinkles decrease skin firmness elasticity by protecting against collagen elastin fiber changes. In addition to retinol’s rejuvenating benefits through direct transcriptional activation, recent studies also suggest an epigenetic regulation micro-RNAs (miR...

Lung cancer early detection by low-dose computed tomography (LDCT) can reduce the mortality. However, LDCT increases the number of indeterminate pulmonary nodules (PNs), whereas 95% of the PNs are ultimately false positives. Modalities for specifically distinguishing between malignant and benign PNs are urgently needed. We previously identified a panel of peripheral blood mononucleated cell (PB...

Dear Editor, A key event in the preparation for pregnancy is the differentiation of human endometrial stromal cells (hESCs) into epithelioid decidual cells. This process, termed decidualization, is initiated in the stromal cells of the superficial endometrial layer 9 days after ovulation. Upon decidualization, hESCs acquire the ability to resist oxidative stress, to modulate immune responses to...

Dear Editor, A key event in the preparation for pregnancy is the differentiation of human endometrial stromal cells (hESCs) into epithelioid decidual cells. This process, termed decidualization, is initiated in the stromal cells of the superficial endometrial layer 9 days after ovulation. Upon decidualization, hESCs acquire the ability to resist oxidative stress, to modulate immune responses to...

Background: Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenet...