BACKGROUND Many efforts have been made to understand basal mechanisms of mycobacterial infections. Macrophages are the first line of host immune defence to encounter and eradicate mycobacteria. Pathogenic species have evolved different mechanisms to evade host response, e.g. by influencing macrophage apoptotic pathways. However, the underlying molecular regulation is not fully understood. A new...

MicroRNAs (miRNA), small noncoding RNA molecules, may regulate protein synthesis, while resistance exercise training (RT) is an efficient strategy for stimulating muscle protein synthesis in vivo. However, RT increases muscle mass, with a very wide range of effectiveness in humans. We therefore determined the expression level of 21 abundant miRNAs to determine whether variation in these miRNAs ...

MicroRNAs (miRNAs) are short regulatory RNA molecules that interfere with the expression of target mRNA by binding to complementary sequences. Currently, the most common method for identification of targets of miRNAs is computational prediction based on free energy change calculations, target site accessibility and conservation. Such algorithms predict hundreds of targets for each miRNA, necess...

Background and aim The incidence of type 2 diabetes mellitus (T2DM) has increased worldwide. One the first actions to reduce risk this disease is implement healthy dietary models; however, no universal strategies have so far been established. In addition, MicroRNAs (miRNAs) are emerging as new biomarkers predict disease. We aimed study whether miRNAs could be used select nutritional therapy pre...

Stratingh Institute for Chemistry, Faculty University of Groningen, Nijenborgh 4, 9747 [email protected] Department of Chemical Engineering, ENTE 9747AG Groningen, The Netherlands Leibniz Institut für Katalyse e. V. an der Un 29a, 18059 Rostock, Germany. E-mail: joha † Electronic supplementary information regarding the synthesis the hosts as wel ELLE experiments. See DOI: 10.1039/c7sc ‡ Both a...

UNLABELLED Small cell lung cancer (SCLC) is a rapidly progressing, incurable cancer that frequently spreads to bone. New insights are needed to identify therapeutic targets to prevent or retard SCLC metastatic progression. Human SCLC SBC-5 cells in mouse xenograft models home to skeletal and nonskeletal sites, whereas human SCLC SBC-3 cells only pervade nonskeletal sites. Because microRNAs (miR...