OBJECTIVES HCV co-infection is a poor prognostic factor in HIV-1-infected patients. Although the number of newly reported patients who show seroconversion is increasing, the clinical features are still unclear, especially in Asian countries. DESIGN A single-center retrospective cohort study of patients diagnosed between 2001-2012. METHODS Acute hepatitis C (AHC) was diagnosed upon detection...

background: the fc receptor like (fcrl) molecules belong to the immunoglobulin (ig) superfamily with potentially immunoregulatoryfunction. among the fcrl family fcrl2 and 4 are predominantly expressed on memory b cells and fcrl1 is a pan- b cell marker. to date, noligand has been identifid for the human fcrl1, 2 and 4 molecules.objectives: cloning, expression, purifiation and structural analysi...

Hepatitis C virus (HCV) is a serious global health issue. Nearly 20% of HCV patients spontaneously clear the virus. While some studies have shown an association spontaneous clearance (SC) with interleukin (IL) 28B single-nucleotide polymorphisms (SNPs), others did not show such relationship. Thus, purpose present study was to investigate IL28B (12979860 SNP) SC infection. Upon initial screening...

Ethnic differences in genetic polymorphisms in UDP-glucuronosyltransferase 1A1 (UGT1A1) were investigated among African-Americans, Caucasians, and Japanese using samples obtained from 150 individuals for each population. Genotyping of -3279T>G in the phenobarbital-responsive enhancer module, TA repeats in the TATA box, 211G>A (G71R) and 686C>A (P229Q) in exon 1, and three single nucleotide poly...

Genetic factors can influence the outcome of antiviral therapy in chronic hepatitis C (HCV). We evaluated the role of interleukin-28B single nucleotide polymorphisms (SNPs) and inosine triphosphatase (ITPA) gene variants in HCV cirrhosis treated with Peg-Interferon and ribavirin. A prospective cohort of 233 patients with compensated cirrhosis received 1-1.5 μg/kg/week of Peg-Interferon alpha-2b...

BACKGROUND In vitro, vitamin B12 acts as a natural inhibitor of hepatitis C virus (HCV) replication. OBJECTIVE To assess the effect of vitamin B12 on virological response in patients with chronic HCV hepatitis naïve to antiviral therapy. METHODS Ninety-four patients with chronic HCV hepatitis were randomly assigned to receive pegylated interferon α plus ribavirin (standard-of-care; SOC) or ...