نتایج جستجو برای: 27
تعداد نتایج: 157360 فیلتر نتایج به سال:
Astronomical data are gathered through a very large number of heterogeneous techniques and stored in very diversified and often incompatible data repositories. Moreover in the e-science environment, it is needed to integrate services across distributed, heterogeneous, dynamic "virtual organizations" formed by different resources within a single enterprise and/or external resource sharing and se...
41 Despite their presence throughout the central nervous system, the impact of axonally 42 expressed gamma-amino-butyric-acid type-A receptors (GABAARs) on neuronal signaling is just 43 beginning to be understood. A recently published article by Jason Pugh and Craig Jahr (2011) 44 tackled this important issue by investigating GABAAR-mediated function in axons of cerebellar 45 granule cells. The...
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). Most cynomolgus monkey P450s are almost identical (‡90%) to human P450s; however, CYP2C76 has low sequence identity (approximately 80%) to any human CYP2Cs. Although CYP2C76 has no ortholog in humans and is partly responsi...
In murine erythroleukemia (MEL) A20 cells (grown in 20 ng/ml adriamycin), mutation(s) producing 10-fold adriamycin (doxorubicin) resistance emerged via an unknown mechanism. Exposure of A20 cells to further stepwise increasing concentrations of ADR in combination with MDR modulators (PSC833 and verapamil) aimed to amplify the undetermined A20 mechanism while controlling P-glycoprotein (P-gp) ov...
Treatment options for ductal adenocarcinoma of the pancreas are limited by early lymphatic spread, but the lymphatic vessels in pancreatic carcinoma have not been studied to date. Here, we present a histomorphological analysis of lymphatic vessels in pancreatic cancer resection specimens. Both intratumoral and peritumoral tissue were devoid of active lymphangiogenesis. Intratumoral lymphatics w...
The last year has been very interesting as far as the APP is concerned. The APP first ever Away Day in November 2007, facilitated by Anton Obholzer, was challenging and stimulating, driven by energy and ideas for change (see page 2). Discussion was heated and included a view that the APP should have a powerful lobbying voice for dynamic practice and analytical thinking in all NHS settings. Ther...
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