A 54-year-old womanwas admitted to our hospital on February 7, 1 994, with persistent productive cough, sore throat, and bloody sputum. She had realized an exacerbation of cough and mucopurulent sputum about 2 months prior to admission and had had bloody sputum on January 3 1. The patient had been in her usual state of health, with productive cough and postnasal drip for a few years; she had th...

Neurocysticercosis is an important cause of seizures in developing countries. Most patients with neurocysticercosis have multiple intra-cranial cystic or calcified lesions. The syndrome of seizures in association with single, small enhancing CT/MRI lesions (SSELs) accounts for about 10% of epilepsy patients seen at major neurological centres in India. The clinical features of this syndrome and ...

STAT3 iswell corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors have remained elusive. In this study, we report the development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a diarylidenyl-piperidone (DAP) backbone to an N-hydroxypyrroline (–NOH) group, which exhibits minima...

Background Fibromyalgia is characterized by chronic inconsistent widespread pain and tenderness. It also associated with other comorbid symptoms like sleep disturbances, fatigue, cognitive impairments (memory mood disturbances), and/or irritable bowel syndrome. [1] Prevalence of fibromyalgia 2.7% globally, being slightly higher in middle aged women (4-9%). 75 to 100 % patients face depression, ...

background ziziphora tenuior l. known as kakuti in persian, is used in traditional medicine for fever, dysentery, uterus infection and as an analgesic. it is used also in the treatment of gastrointestinal disorders as carminative, or remedy of diarrhea or nausea. major components of plant essential oil including pulegone, isomenthone, thymol, menthone, and piperitone are suggested to be respons...

Meiosis I in males of the Dipteran $ciara coprophila results in the nonrandom distribution of maternally and paternally derived chromosome sets to the two division products. Based on an earlier study (Kubai, D. E 1982. J. Cell Biol. 93:655-669), I suggested that the meiosis I spindle does not play a direct role in the nonrandom sorting of chromosomes but that, instead, haploid sets are already ...

Mineral nutrients such as Phosphorus and Zinc are getting scarcer worldwide. Unlike fossil fuels, for which over time substitutes can be developed, these nutrients cannot be substituted as they are essential for life on earth. For instance, in both plants and animals Phosphorus is a component of DNA, RNA, ATP and of phospholipids which form all cell membranes. Phosphorus is thus essential for t...

Objectives: We assessed the comparative efficacy and tolerability of topiramate (TPM), lamotrigine (LTG), gabapentin (GBP) and clobazam (CLB) with an aim to formulate clinical guidelines while initiating treatment with new anti-epileptic drugs (AEDs). Methods: A prospective open label, nonrandomized, add-on study was conducted on 203 Indian patients with seizures refractory to conventional AEDs...

Cereal Chem. 72(2):213-216 Diploid wheat (Triticum monococcum L., einkorn) is of interest both species of wheat and among diploid wheat strains were minimal, especially as a crop and as a source of genes unavailable in the more widely grown after amino acid values were adjusted to a common protein level. One wheat species, T. aestivum L. (common wheat) and T. durum Desf. (durum of the einkorn a...