Differentially regulated microRNA (miRNA) are associated with hepatic fibrosis; however, their potential usefulness for blocking hepatic fibrosis has not been exploited fully. We examined the expression of miRNA in the liver of a transgenic mouse model in which platelet-derived growth factor C (PDGF-C) is overexpressed (Pdgf-c Tg), resulting in hepatic fibrosis and steatosis and the eventual de...

Hypoxia-induced pulmonary hypertension (PH), which is characterized by vascular remodeling of blood vessels, is a significant complication of chronic obstructive pulmonary disease (COPD). In this study, we screened 13 candidate miRNAs in pulmonary artery smooth muscle cells (PASMCs) harvested from COPD patients with PH (n = 18) and normal controls (n = 15) and found that the expression of miR-2...

Fusarium wilt (FW), caused by Fusarium oxysporum f. sp. ciceris and Ascochyta blight (AB), caused by Ascochyta rabiei are two major constraints to chickpea production. Therefore, two parallel marker-assisted backcrossing (MABC) programmes by targeting foc 1 locus and two QTL regions, ABQTL-I and ABQTL-II were undertaken to introgress resistance to FW and AB, respectively in C 214, an elite cult...

Gemcitabine (GEM), a commonly used chemotherapeutic agent in hepatocellular carcinoma (HCC) patients, uses oxidative stress induction as a common effector pathway. However, GEM alone or in combination with oxaliplatin hardly renders any survival benefits to HCC patients. We have recently shown that this is part due to the overexpression of the mitochondrial uncoupling protein 2 (UCP2) that in t...

Abstract Aim Suspected biliary pathology necessitates imaging to assess for gallstones. Ultrasound is gold-standard but often limited by bowel gas/body habitus. MRCP has become popular due superior ability detect CBD stones. CT used with concerns of a wider differential diagnosis. This study aimed explore the diagnostic journey suspected gallstone patients, and whether increased furthered patie...

Periodontitis is the main cause of adult tooth loss. Stem cell-based tissue engineering has become a promising therapy for periodontitis treatment. To date, human periodontal ligament stem cells (hPDLSCs) have been shown to be a favorable source for tissue engineering, but modulatory mechanisms of hPDLSCs remain unclear. Approximately 60% of mammalian genes are the targets of over 2000 miRNAs i...

The abstraction of the active hydrogen of RCOCH2R by a base catalyst B M , and the subsequent formation of the enolate [RCOCHR ] M are described in Eq. 1 (deprotonation process). Secondly, the creation of a C–N bond, in which [RCOCHR ] M reacts with R ONO to form complex [RCOCHNO(OR )R ] M , is shown in Eq. 2 (C–N bond formation process). Finally, the reaction between [RCOCHNO(OR )R ] M with ba...

BACKGROUND miRNAs are non-coding RNAs that regulate gene expression in a wide range of biological contexts, including a variety of diseases. The present study clarified the role of miR-214-5p in hepatic fibrogenesis using human clinical tissue samples, livers from rodent models, and cultured hepatic stellate cells. METHODS The expression of miR-214-5p and genes that are involved in liver fibr...