Introduction ........................................................................................610 I. Business and Technological Realities in the World of Biotechnology ...........................................................................611 II. Reach-Through Patent Claims .................................................616 III. Fundamental Legal Framework for Treatment of ReachThr...

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climatological parameters are among the most important ecological capability evaluation criterias, on other hand, climate changes which has intensified in the past decades and has the consequences such as; increases in climatic threshold phenomena like occurrence of horrific floodings, destructive hurricanes, abnormal and sudden colds and heats, untimely rainfalls and heavy snows, widespread dr...

Long-term effects of a novel angiotensin converting enzyme (ACE) inhibitor, CS-622, on Ca-dependent tone in aortic smooth muscles of spontaneously hypertensive rats (SHR) were examined. CS-622 (3 or 10 mg/kg/day), when orally administered to SHR for 21 weeks, exhibited a dose-dependent antihypertensive action. In Krebs-Henseleit solution, removal of Ca caused much greater relaxation in aortas e...

Stochastic weather generators are used in different studies which often require long series of daily weather data for risk assessment. They can produce synthetic daily time series of any length. Any generator should be tested to ensure that the synthetic data is proper for the purposes for which it is to be used. The main objective of this paper is to test a stochastic weather generator, LARS-W...

I have enjoyed reading the work of each of these authors over the years, so it is a real pleasure to have this opportunity to contribute to the discussion of this collaboration. The geometry of LARS furnishes an elegant bridge between the Lasso and Stagewise regression, methods that I would not have suspected to be so related. Toward my own interests, LARS offers a rather different way to const...

Metastatic spread of cancer cells portends a poor prognosis and mortality for lung cancer patients. Hypoxia-inducible factor-1α (HIF-1α) enhances tumor cell motility by activating the epithelial-to-mesenchymal transition (EMT), which is considered a prerequisite for metastasis. Recent studies of microRNA involvement in cancer invasion and metastasis have highlighted the role of such RNAs in tum...