A bioassay of N-nitrosodiphenylamine for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered N-nitrosodiphenylamine at one of two doses, either 1,000 or 4,000 ppm, for 100 weeks. Matched controls consisted of 20 untreated rats of each sex. All surviving rats were killed at the end of admi...

Acute and Subchronic Inhalation Toxicity of Chloroform in Rats and Mice: Tatsuya KASAI, et al. Japan Bioassay Research Center—In order to better characterize acute and subchronic toxicities of chloroform and to provide its basic toxicity data for risk assessment of humans exposed to chloroform in work and living environments, mice and rats of both sexes were exposed by inhalation to chloroform ...

OBJECTIVE To observe the effects of lead acetate and protective role of garlic extract on the histomorphology of the ovary in an animal model. METHODS The experimental trial was conducted at the Department of Anatomy, Army Medical College Rawalpindi, in association with the National Institute of Health (NIH), Islamabad, from April to June 2013. It comprised 30 adult non-pregnant female mice (...

A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown. To identify genes associated with aging-related renal infiltration, we analyzed kidneys from aged mice (≥20 strains) for infiltrating leukocytes followed by Haplotype Association Mapping (HAM) ...

A bioassay of trimethylphosphate for possible carcinogenicity was conducted by administering the compound by gavage to Fischer 344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were administered trimethylphosphate in distilled water three times per week at one of two doses, either 50 or 100 mg/kg body weight for the rats and either 250 or 500 mg/kg body weight for the mice. Ve...

Dicopper(II) tetrakis(3,5-diisopropylsalicylate), [Cu(II)(2)(3,5-DIPS)(4)], is effective in increasing survival of lethally irradiated mice when it is administered after irradiation. The possibility that this radiorecovery activity might also facilitate recovery from radiation-induced impaired increase in body mass and locomotion was examined. Cu(II)(2)(3,5-DIPS)(4) was used to treat LD 50/30 g...

A bioassay of phthalamide for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered phthalamide at one of two doses, either 15,000 or 30,000 ppm for the males and either 5,000 or 10,000 ppm for the females, for 106 weeks. Groups of 50 mice of each sex were administered the test chemical at ...

1 Helminths facilitate their own survival by actively modulating the immune systems of 2 their hosts. We investigated the impact different life-cycle stages of the rodent filaria 3 Litomosoides sigmodontis have on the inflammatory responses of mice injected with sub4 lethal doses of lipopolysaccharide (LPS). Mice infected with female adult worms from 5 prepatent infections, those which have not...

The cytokines IFN-?, interleukin IL-1?, and TNF-? each up regulate the expression of major histocompatibility complex (MHC) are therefore considered as inflammatory markers. present study aimed to measure serum levels in mice after induction diabetes with streptozotocin correlate their lipid glycaemic profiles. included 40 Swiss Albino (20 males 20 females), half male female groups were made di...