Background: Cutaneous leishmaniasis is a common parasitic disease in Iran being mainly caused by Leishmania (L.) major. The aim of this study was to investigate the occurrence of apoptosis in the spleen and liver of female mice infected with L. major.Methods: BALB/c mice were randomly assigned into the control and experimental groups (ten mice per group). The experimental groups were subcutaneo...

the affinity of low density lipoprotein(ldl) to its receptor is very important, because most of ldl-uptake pathway is done by the ldl receptor and the change in size of ldl particle and the modification in its components may affect the ldl affinity for its receptor. in this study, the effects of a powerful lipid-soluble antioxidant “ubiquinol-10” have been investigated on the affinity of ldl to...

The enzyme carbamyl phosphate-aspartate transcarbamylase catalyzes the transfer of the carbamyl group from carbamyl phosphate (CP) to L-aspartate ($). Preliminary experiments with a series of six relatively advanced azo dye-induced hepatomas indicated that hepatoma tissue had a higher CP-aspartate transcarbamylase activity than did liver from normal animals. Experiments are reported here in whi...

in order to study the effect of garlic crude extract on growth rate and histopathology of liver, kidney and intestinal bulb, 120 fishes with initial mean weight of 95±22 g were divided to four groups. they were fed with 0, 10, 20 and 40 g/kg garlic crud extract in food for 1 month. at the end of experimental period, the growth rate was estimated and samples from liver, kidney and intestinal bul...

Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologi...