OBJECTIVE The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. MATERIAL AND METHODS In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

The differential actions of i.v. arecoline and nicotine were determined on neocortical and limbic system EEG activation in acute rostra1 and caudal midbrain transected cats. All animals were prepared under diethyl ether anesthesia and after surgery, paralyzed with decamethonium and maintained on artificial respiration. The peripheral effects of these cholinergic agonists were reduced by methyl ...

SUBJECTS, MATERIALS, AND METHODS DRUG ADMINISTRATION HALLUCINOGEN RATING SCALE STATISTICS RESULTS 0.4-MG/KG DOSE PERCEPTION SOMAESTHESIA AFFECT COGNITION VOLITION INTENSITY 0.2-MG/KG DOSE 0.1-MG/KG DOSE 0.05-MG/KG DOSE HALLUCINOGEN RATING SCALE TECHNICAL COMMENT ON ASSESSMENT OF SUBJECTIVE EFFECTS COMMENT REFERENCES

Background and Aims: Quantum dots (QDs), as colloidal nanocrystalline semiconductors, present QD wavelengths in terms of biomedical assays and imaging, though the high toxicity of their core demands to be taken into consideration. Investigating this subject is taken into account as an important concept   concerning use of these nanoparticles in the medical applications. Materials a...

l-Tetrahydropalmatine (l-THP) is an active ingredients of Corydalis yanhusuo W.T. Wang, which protects against acute global cerebral ischaemia-reperfusion injury. In this study, we show that l-THP is cardioprotective in myocardial ischaemia-reperfusion injury and examined the mechanism. Rats were treated with l-THP (0, 10, 20, 40 mg/kg b.w.) for 20 min before occlusion of the left anterior desc...

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

BACKGROUND Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in immature rats. To know if some changes persist into adulthood we studied these models in young adult Wistar rats. METHODS Caffeine treatment at a daily dose of 10 and/...

BACKGROUND The induction dose of propofol is reduced with concomitant use of opioids as a result of a possible synergistic action. AIM AND OBJECTIVES The present study compared the effect of fentanyl and two doses of butorphanol pre-treatment on the induction dose of propofol, with specific emphasis on entropy. METHODS Three groups of 40 patients each, of the American Society of Anaesthesio...

to determine the neuropharmacological activity of the leaf extract of croton zambesicus in mice and chicks. the effect of aqueous leaf extract of croton zambesicus on thiopental sodium – induced sleeping time in mice, on gross locomotor activity (gla) in 2-day old chicks and effect of extract on apomorphine - induced stereotyped behavior in chicks were evaluated. the aqueous extract (1000 and 1...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as well as Alzheimer›s disease and stroke. However, the potential benefits of creatine for patients...