The effects of phenylethylbiguanidide, decamethylenediguanidide, and octylguanidine have been studied with mung bean hypocotyl mitochondria (Phaseolus aureus var. Jumbo) supplied with malate, reduced nicotinamide adenine dinucleotide, succinate, or ascorbate-tetramethyl-p-phenylenediamine as substrates. The guanidines act as energy transfer inhibitors, all three inhibiting all three phosphoryla...

The metabolism of 2-acetylaminofluorene (AAF) as well as the activation of AAF to covalently bound and mutagenic intermediates were studied in isolated rat hepatocytes. The cell system readily formed oxidized, deacetylated, and conjugated AAF metabolites. Pretreatments of animals with the inducer beta-naphthoflavone led to increases in phenolic and conjugated as well as covalently protein-bound...

A bioassay of N-phenyl-p-phenylenediamine for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer 344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered N-phenyl-p-phenylenediamine at one of two doses, either 600 or 1,200 ppm, for 78 weeks and were then observed for 26 additional weeks. Matched controls consisted of groups of 20 un...

Here, we report a facile strategy for the synthesis of cadmium and cobalt metal-organic frameworks (MOFs), their subsequent conversion to corresponding oxide. Thus, Cd-MOF Co-MOF were prepared by successive ionic layer adsorption reaction (SILAR) using Cd 2+ or Co cation precursors p -phenylenediamine (PPD) anion precursor. As-synthesized particles with unique morphology converted into CdO 3 O ...

ni2+ supported on hydroxyapatite-core@shell γ-fe2o3 nanoparticles (γ-fe2o3@hap-ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °c. this reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high...

Synthesis of Some Benzimidazole derivatives 4'-(5, 6-substitued-2-trifluoromethylbenzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid were synthesized by condensation of various steps with different o-Phenylenediamine was condensed with in propylene glycol was added trifluoroacetic acid in the presence of BF3•OEt2 as catalysis. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the ...

In the search of new organometallic precursors, this contribution describes a convenient synthesis to obtain ferrocene-based sulfonyl diamine derivatives. The [(η5-C5H4SO2NH-CH2-CH2-NH2)Fe(η5-C5H5)] (1) and [(η5-C5H4SO2NH-C6H4-NH2)Fe(η5-C5H5)] (2) compounds were prepared by reaction between (η5-C5H4SO2Cl)Fe(η5-C5H5) respective precursor: ethylenediamine or p-phenylenediamine in good yield...

We have developed a new method for determination of serum ceruloplasmin from its oxidase activity, in which o-dianisidine dihydrochioride is used as substrate. o-Dianisidine dihydrochloride is more stable than is the more widely used p-phenylenediamine substrate, and forms a stable product that is measured at 540 nm. Correlation was good between results of this method and those obtained with bo...

The ability of the electron transport particulate fraction of Azotobacter vinelandii strain O to oxidize tetramethyl-p-phenylenediamine (TMPD) and p-phenylenediamine (PPD) was examined in detail. The highest specific activity for TMPD and PPD oxidation concentrated in the A. vinelandii O R(3) fraction. The A. vinelandii O R(3) fraction was used to develop a standard manometric assay which gave ...