A 7-year-old boy presented with recurrent cholangitis, failure to thrive, and progressive splenomegaly. On examination, he had severe pallor, clubbing, and splenohepatomegaly. Lab results showed anemia (hemoglobin 7.2 g/dL) and normal liver functions. Abdominal ultrasound showed hepatosplenomegaly with coarsened liver echotexture and multifocal intrahepatic biliary radical (IHBR) dilatation. Th...

Post-registration studies describe parameters of real-life clinical practice such as the treated population, conditions of treatment initiation, treatment duration, adherence, associated benefits/risks as well as the impact on treatment strategies, healthcare procedures and on public health. The results of these studies are used in particular for re-evaluation, re-registration or in application...

* Facultad de Ciencias Económicas y Empresariales, Universidad de Málaga, Spain. Email: [email protected] ° Department of Economics, Bar-Ilan University, 52900 Ramat-Gan, Israel, and Senior Research Fellow, CEPS/INSTEAD, Esch-sur-Alzette, Luxembourg. Email: [email protected] This study has been prepared within the OPHI theme on multidimensionak poverty measurement. OPHI gratefully acknowledg...

Current urban city logistics literature often claims that rising e-commerce and the associated courier-, express- parcel- (CEP) deliveries are inherently responsible for increase in road traffic related congestion, disturbances delays within cities. However, existing research is so far limited concerning studies to what extent CEPs impact contribute traffic, particularly comparison with other c...

Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. The basal body that functions in PC assembly is derived from the mature centriole, a component of the centrosome. Through a sma...

There is still controversy regarding the role of circulating endothelial and progenitor cells (CECs/CEPs) in the pathogenesis of systemic sclerosis (SSc). Using a sequential Boolean gating strategy based on a 4-color flow cytometric protocol, an increased number of CD31(pos)/CD184(pos)(CXCR4)/CD34(pos)/CD45(pos) and CD31(pos)/CD117(pos) (c-kit-R) /CD34(pos)/ CD45(pos) hematopoietic circulating ...

Due to the lack of consistent data, direct and robust comparisons of cross-country labour markets have been virtually impossible. This study uses a new panel data series that controls for inconsistencies, thus overcoming this problem. This study estimates gender wage differentials and gender discrimination in the German and United Kingdom labour markets. Panel estimates are used to identify gen...

Congenital extrahepatic portosystemic shunt (CEPS) is a rare disorder characterised by partial or complete diversion of portomesenteric blood into systemic veins via congenital shunts. Type I is characterised by complete lack of intrahepatic portal venous blood flow due to an end to side fistula between main portal vein and the inferior vena cava. Type II on the other hand is characterised by p...

A recent ‘Number Check' article in the American College of Cardiology's monthly magazine realerted me to havoc diabetes (1). The provided following sobering data U.S. population: 11.3% has type 2 (T2D). And while this is alarming because cost for caring these patients and downstream adverse health effects likely occur, I was surprised find out that South Asians living U.S., an estimated 23% hav...