Amemiya, Morimasa, Kaoru Tabei, Eiji Kusano, Yasushi Asano, and Robert J. Alpern. Incubation of OKP cells in low-K1 media increases NHE3 activity after early decrease in intracellular pH. Am. J. Physiol. 276 (Cell Physiol. 45): C711–C716, 1999.—Chronic hypokalemia increases the activity of proximal tubule apical membrane Na1/H1 antiporter NHE3. The present study examined the effect of the incub...

Rogausch, Heinz, Adriana Del Rey, Jörg Oertel, and Hugo O. Besedovsky. Norepinephrine stimulates lymphoid cell mobilization from the perfused rat spleen via b-adrenergic receptors. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R724–R730, 1999.—The possibility that norepinephrine (NE) influences lymphoid cell outflow independently of its vasoconstrictor action was investigated ...

Fanestil, Darrell D., Duke A. Vaughn, Ronald H. Hyde, and Patricia Blakely. Genetic control of renal thiazide receptor response to dietary NaCl and hypertension. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R901–R904, 1999.—Excess NaCl increases blood pressure in some strains of animals but not others. An 8% NaCl diet did not change renal thiazide receptor (TZR) density in tw...

Park, Kyoung Sik, Tae Kon Kim, and Do Han Kim. Cyclosporin A treatment alters characteristics of Ca21-release channel in cardiac sarcoplasmic reticulum. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H865–H872, 1999.—Chronic treatment with cyclosporin A (CsA) has been reported (H. S. Banijamali, M. H. ter Keurs, L. C. Paul, and H. E. ter Keurs. Cardiovasc. Res. 27: 1845–1854, 1993; I. Kingma, E...

Hashimoto, M., K. Shinozuka, Y. Tanabe, S. Gamoh, T. Hara, M. S. Hossain, Y. M. Kwon, M. Kunitomo and S. Masumura. Hypotension induced by exercise is associated with enhanced release of adenyl purines from aged rat artery. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H970–H975, 1999.—To determine whether the antihypertensive effects of exercise are associated with release of ATP and its metab...

ROLAND SCHMITT,1 DAVID H. ELLISON,2 NICOLETTE FARMAN,5 BERNARD C. ROSSIER,3 ROBERT F. REILLY,2 W. BRIAN REEVES,4 ILSE OBERBÄUMER,1 ROSEMARIE TAPP,1 AND SEBASTIAN BACHMANN1 1Institut für Anatomie, Charité, Humboldt Universität, D-10098 Berlin, Germany; 2University of Colorado Health Sciences Center and Veterans Affairs Medical Center, Denver, Colorado; 3Institut de Pharmacologie et de Toxicologi...

Verheijck, E. Etienne, Antoni C. G. van Ginneken, Ronald Wilders, and Lennart N. Bouman. Contribution of L-type Ca21 current to electrical activity in sinoatrial nodal myocytes of rabbits. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1064–H1077, 1999.—The role of L-type calcium current (ICa,L) in impulse generation was studied in single sinoatrial nodal myocytes of the rabbit, with the use o...

Prakash, Y. S., A. A. Togaibayeva, M. S. Kannan, V. M. Miller, L. A. Fitzpatrick, and G. C. Sieck. Estrogen increases Ca21 efflux from female porcine coronary arterial smooth muscle. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H926–H934, 1999.—Acute estrogen administration relaxes vascular smooth muscle by decreasing intracellular Ca21 concentration ([Ca]i). In the present study, we examined...

A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the...