Western equine encephalitis virus (WEEV) is a naturally occurring recombinant virus derived from ancestral Sindbis and Eastern equine encephalitis viruses. We previously showed that infection by WEEV isolates McMillan (McM) and IMP-181 (IMP) results in high (∼90-100%) and low (0%) mortality, respectively, in outbred CD-1 mice when virus is delivered by either subcutaneous or aerosol routes. How...

BACKGROUND There is a high prevalence of HIV/syphilis among male sex workers, but no formal study has ever been conducted focusing on male clients of male sex workers (MCM). A detailed investigation was thus called for, to determine the burden and sociobehavioral determinants of HIV and syphilis among these MCM in China. METHODS As part of a multicenter cross-sectional study, using respondent...

Blast furnace slag (BFS) was added into drilling fluid as a mud cake modifier (MCM) for the reuse of BFS. The effects of MCM on drilling fluid rheology and shear strength of cementformation interface (SSCFI) were evaluated. The experimental results showed that the optimized formula of the drilling fluid has 1.0 wt% MCM. The simulation results showed that SSCFI increased significantly with the a...

INTRODUCTION Limited data exist on the outcome of Dandy-Walker malformation (DWM), Dandy-Walker variant (DWV) and mega-cisterna magna (MCM). We report the first population-based study of posterior fossa anomalies from the northern region of England. METHODS Cases were identified from the Northern Congenital Abnormality Survey (NorCAS) and regional Fetal Medicine Unit databases for the period ...

This paper describes the system packaging of the processor cage for the IBM eServer z900. This server contains the world’s most complex multichip module (MCM), with a wiring length of 1 km and a maximum power of 1300 W on a glass-ceramic substrate. The z900 MCM contains 35 chips comprising the heart of the central electronic complex (CEC) of this server. This MCM was implemented using two diffe...

When individuals learn facts (e.g., foreign language vocabulary) over multiple study sessions, the temporal spacing of study has a significant impact on memory retention. Behavioral experiments have shown a nonmonotonic relationship between spacing and retention: short or long intervals between study sessions yield lower cued-recall accuracy than intermediate intervals. Appropriate spacing of s...

s for Invited Talks 8 Workshop on Monte Carlo for Financial Mathematics 12 Workshop on Monte Carlo for Computational Biology 15 Abstracts for Talks 18 Welcome to MCM 2007s for Talks 18 Welcome to MCM 2007 On behalf of the programme committee and the local organising committee, it is my pleasure to welcome you to the sixth International Association for Mathematics and Computers in Simulation sem...

This study aimed to assess the effect of intracellular prolactin (ICPRL) and hyperprolactinemia on cell replication, using an immunohistochemical (IHC) technique for Ki-67 and Mcm-2, and angiogenesis, using IHC for endoglin CD-105, in central nervous system (CNS) tumors. This cross-sectional study included 79 cases of surgically excised primary CNS tumors of neuroepithelial origin (41.8% of all...

BACKGROUND The origin recognition complex (ORC) and the minichromosome maintenance (MCM) protein complex were initially discovered in yeast and shown to be essential for DNA replication. Homologues of ORC and MCM proteins exist in higher eukaryotes, including Xenopus. The Xenopus MCM proteins and the Xenopus homologues of Saccharomyces cerevisiae Orc 1p and Orc2p (XOrc1 and XOrc2) have recently...

The MCM (minichromosome maintenance) proteins of archaea are widely believed to be the replicative DNA helicase of these organisms. Most archaea possess a single MCM orthologue that forms homo-multimeric assemblies with a single hexamer believed to be the active form. In the present study we characterize the roles of highly conserved residues in the ATPase domain of the MCM of the hyperthermoph...