نتایج جستجو برای: 177lu edtmp
تعداد نتایج: 871 فیلتر نتایج به سال:
UNLABELLED The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreota...
Peptide receptor radionuclide therapy (PRRT) is an effective MRT (molecular radiotherapy) treatment, which consists of multiple administrations of a radiopharmaceutical labelled with 177Lu or 90Y. Through sequential functional imaging a patient specific 3D dosimetry can be derived. Multiple scans should be previously co-registered to allow accurate absorbed dose calculations. The purpose of thi...
Combination of therapies is a common strategy in cancer treatment. Such combined only have merit provided that there superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility combine chemotherapy radionuclide therapy using polymeric micelles as delivery vehicle. For purpose, prepares poly(ε-caprolactone-b-ethylene oxide) (PCL-PE...
To examine the impact of acquisition time on Lutetium-177 (177Lu) single-photon emission computed tomography (SPECT) images using Monte Carlo simulation. A gamma camera simulation based method was performed to produce SPECT images. The phantom modeled a NEMA IEC BODY including six spheres as tumors. After administration 7.4 GBq 177Lu, radioactivity concentrations tumor/liver at 6, 24, and 72 h ...
PurposePatient-specific dosimetry in MRT relies on quantitative imaging, pharmacokinetic assessment and absorbed dose calculation. The DosiTest project was initiated to evaluate the uncertainties associated with each step of clinical workflow through a virtual multicentric trial. This work presents generation simulated SPECT datasets based GATE Monte Carlo modelling its corresponding experiment...
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