Sexually mature pigs are known to possess high concentrations of testicular steroids, which have been shown to change the activities of cytochrome P450 in vitro. The aim of the present study was to evaluate the regulation of CYP1A and CYP2E1 activity by the steroids dihydrotestosterone (DHT), 3β-androstenol, 17β-estradiol and 17α-estradiol. Catalytic activities of 7-ethoxyresorufin O-deethylase...

Mitochondria-derived danger-associated molecular patterns (DAMPs) play important roles in sterile inflammation after acute injuries. This study was designed to test the hypothesis that 17β-estradiol protects the heart via suppressing myocardial mitochondrial DAMPs after burn injury using an animal model. Sprague-Dawley rats were given a third-degree scald burn comprising 40% total body surface ...

the correlation between serum steroid hormones, testosterone (t), 17β-estradiol (e2), and progesterone (p) and weight of female fishes, biological characteristics of gonad (e.g. fertilization rate, fluid egg rate, gonadosomatic index , polarization index and oocyte diameter) in 10 female of the migratory population of sterlet (acipenser ruthenus) and 5 female of the migratory population of sibe...

Miroestrol and deoxymiroestrol are phytoestrogens isolated from tuberous root of Pueraria candollei var. mirifica. Modulatory effects of miroestrol and deoxymiroestrol on enzymes involved in sex-hormone synthesis pathway in male C57BL/6 mice were investigated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Miroestrol and deoxymiroestrol suppressed the expressio...

Objective(s): The current investigation was undertaken to evaluate the effects of 17β- estradiol (17β-ED) on the potential of the mesenchymal stem cells (MSCs) for modulation of immunity responses in an animal model of multiple sclerosis (MS).Materials and Methods: After isolation of MSCs, cells were cultured in presence of 100 nM 17β-ED for 24 hr. Modeling of experimental autoimmune encephalom...

The aim of this study was to determine the correlation between the level of calcium in the mandible and teeth and the level of alkaline and acid phosphatases in ovariectomized rats with or without supplementation of 17β-estradiol. Rats were qualified for the following groups: Cl – control, SH – sham operated, OV – ovariectomized, OVH – ovariectomized and receiving 17β-estradiol in three differe...

OBJECTIVES Aromatase inhibitors that block estrogen synthesis are a proven first-line hormonal therapy for postmenopausal breast cancer. Although it is known that standardized extract of Ginkgo biloba (EGb761) induces anti-carcinogenic effects like the aromatase inhibitors, the effects of EGb761 on steroidogenesis have not been studied yet. Therefore, the effects of EGb761 on steroidogenesis an...

INTRODUCTION Decreasing of testosterone level is an important part of a male elderly. MATERIAL AND METHODS To describe this phenomenon a PubMed and national databases were searched for 17β-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men. RESULTS The reduction in intensity of the processes of tissue ren...

Although neuroactive steroids exert neuroprotective actions in different experimental models of neurodegenerative diseases, including those of Alzheimer's disease (AD), their relationships with aged related physiologic and pathologic brain changes remain to be clarified. In this study the levels of pregnenolone, dehydroepiandrosterone, progesterone, dihydroprogesterone, tetrahydroprogesterone, ...