PURPOSE Integrins are expressed by numerous tumor types including breast cancer, in which they play a crucial role in tumor growth and metastasis. In this study, we evaluated the ability of ATN-161 (Ac-PHSCN-NH2), a 5-mer capped peptide derived from the synergy region of fibronectin that binds to alpha5beta1 and alphavbeta3 in vitro, to block breast cancer growth and metastasis. EXPERIMENTAL ...

This article gives guidance for the handling and examination of various types of lung tissue specimens to provide: (1) accurate diagnosis and assessment of severity of disease; (2) suYcient information for the accurate staging of tumours; and (3) an assessment of the contribution of various occupational disorders to the cause of death. (J Clin Pathol 2000;53:507–512)

OBJECTIVES To determine the specific clinical aspects of patients with suicidal behaviour by firearm and investigate the specificities of the suicide method. BACKGROUND Suicidal behaviour represents a major public health problem throughout the world. Attempted suicide and completed suicide by firearms rates are very high both in Europe and in the United States. Preventive aspects presently pr...

PURPOSE To determine the incidence of exercise-associated hyponatremia (EAH), the associated biochemical measurements and risk factors for EAH, and whether there is an association between postrace blood sodium concentration ([Na+]) and changes in body mass among participants in the 2009 Western States Endurance Run, a 161-km mountain trail run. METHODS Change in body mass, postrace [Na+], and...

BACKGROUND Actinic cheilitis (AC) is a potentially malignant disorder of the lip caused by chronic exposure to ultraviolet radiation from the sun. OBJECTIVES To evaluate the clinical, demographic, morphological and therapeutic management in AC cases data associating to the histopathological grading. METHODS Demographic, clinical and management data of 161 patients with AC were analyzed. In ...

Presentism used to be so simple. In the old vernacular it referred a tendency view past from perspective of present (or, at its most extreme, maybe even use illuminate present). Historians disagreed furiously on intellectual virtues orienting their views needs current day. But content term itself was rarely disputed.