Ben-Tabou De-Leon, Shlomo, Galia Ben-Zeev, and Itzhak Nussinovitch. Effects of osmotic shrinkage on voltage-gated Ca channel currents in rat anterior pituitary cells. Am J Physiol Cell Physiol 290: C222–C232, 2006. First published September 7, 2005; doi:10.1152/ajpcell.00118.2005.—Increased extracellular osmolarity ([Os]e) suppresses stimulated hormone secretion from anterior pituitary cells. C...

A 52-year-old woman presented with abdominal distension. The laboratory data were as follows: white blood cell count, 7.100/mm3; hemoglobin, 12.2g/dL; platelet count, 206.000/mm3; blood urea nitrogen, 16.8mg/dL; serum creatinine, 1.6mg/dL; sodium, 146mEq/L; potassium, 3.2mEq/L; chloride, 94mEq/L; glucose, 110mg/dL; total protein, 8.6g/dL; and albumin, 4.9g/dL. Random urine protein concentration...

The therapeutic efficacy of imatinib mesylate (Gleevec) is based on its specific inhibition of the BCR-ABL oncogene protein, a widely expressed tyrosine kinase in chronic myelogenous leukemia (CML) cells. The goal of this study was to evaluate glucose metabolism in BCR-ABL-positive cells that are sensitive to imatinib exposure. Two human BCR-ABL-positive cell lines (CML-T1 and K562) and one BCR...

There are many methods for modeling species distribution in the landscape. In this chapter, the authors elaborate on the concepts of species modeling and present three popular techniques to generate species distribution: cartographic overlay, logistic multiple regression and maximum entropy (MAXENT). The cartographic overlay method is relevant to generate a habitat suitability index. Logistic m...

[(125)I](T,G)-A--L-binding T cells have been studied in mice whose ability to mount an immune response to (T,G)-A--L is under control of the H-2-linked Ir-1A gene. Nonimmunized high and low responder mice have approximately the same frequency of T-ABC. Following immunization, T-ABC proliferated only in high responders, but not in low responders, indicating expression of Ir-1A in T cells. When, ...

HeLa cells were exposed to formaldehyde and its metabolic derivatives, methanol, formic acid, and acetaldehyde, to investigate that the toxicity of formaldehyde is not caused by the chemical group. After 1 h of treatment with formaldehyde, mitochondrial assays showed that low concentrations (e.g. 10 μmol/L) of formaldehyde promoted growth of the HeLa cells, while higher concentrations (e.g. ≥62...

Increased extracellular osmolarity ([Os]e) suppresses stimulated hormone secretion from anterior pituitary cells. Ca2+ influx may mediate this effect. We show that increase in [Os]e (by 18-125%) differentially suppresses L-type and T-type Ca2+ channel currents (IL and IT, respectively); IL was more sensitive than IT. Hyperosmotic suppression of IL depended on the magnitude of increase in [Os]e ...

Owing to its toxicity, aluminum (Al), which is one of the most abundant metals, inhibits the productivity of many cultures and affects the microbial metabolism. The aim of this work was to investigate the capacity of sugar cane vinasse to mitigate the adverse effects of Al on cell growth, viability, and budding, as the likely result of possible chelating action. For this purpose, Fleischmann's ...

Seven CA 125 immunoassays were compared for their clinical performance. CA 125 concentrations were determined in 289 serum samples obtained from women with benign pelvic tumors (samples from 98 patients) and patients with various cancers (samples from 111 patients). In the range of 0-1000 kilounits/L, all assays tested were linearly correlated, with correlation coefficients ranging from 0.89 to...

Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs) nanoparticles (NPs), UiO-66 (~100 nm) and MIL-125 (~100 nm), were embedded separately into thin-film composite membranes in different...