Isatin (1H-indole-2,3-dione), an indole derivative of plant origin, is involved in many pharmacological activities like antiallergic, antimalarial, antiviral and antimicrobial; isatin and its derivatives have been found to show promising results against various cancer cell lines. Isatin is a versatile precursor for many biologically active molecules and its diversified nature makes it a versati...

In the present work, novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/NaNO2 with yields of 64-74%. Cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (K562, LS180...

In the presence of IR irradiation by the use of solid support montmorillonite KSF, under solvent free conditions four component aldehyde, Dione, Meldrum acid and ammonium acetate react for the formation of 1, 4 dihydropyridine derivatives. This is a greener method and one pot synthesis. Minimum reaction time and higher yield are the advantages of this process. The product can be purifying by ch...

A new class of quinoline derivatives containing pyrazoline-5-one and pyrazole moiety (3a-j and 4a-j) have been synthesized by condensation of various oxobutyrates/pentane-2,4-dione derivatives with 8-quinolinoxyacetic acid hydrazide. Elemental analysis, IR, H NMR and mass spectral data support the structures of the newly synthesized compounds. The synthesized compounds have been evaluated for t...

Pyrrolizidine alkaloid derivatives are present in the androconial (male scent) organs of Prittwitzia hymenaea, Mechanitis isthmia veritabilis, Tithorea harmónia fúria (Lep., Ithomiinae), Amauris echeria and Euploea sylvester (Lep., Danainae). While the ithomiines contain the new pyrrolizidine alkaloid derivative methyl hydroxydanaidoate, the danaines contain the known derivatives danaidone and ...

Herein, novel europium(III) complex derivatives dedicated to polymer chemistry applications as molecular sensors have been reported. The following are among them tris(4,4,4-trifluoro-1-phenylbutane-1,3-dione)europium(III) (BTA) and tris(4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dione)europium(III)] (NTA). To obtain the relevant europium complexes, they were coordinated with corresponding ligands...

5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from reaction (1) thiating Lawesson Japanese ...

Azalactone 1 can be synthesized via treatment of 4chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydroch...

New 1-benzhydryl-3-phenylurea derivatives and their 1-benzhydryl-3-phenylthiourea isosteres were synthesized and evaluated for their human CB1 and CB2 cannabinoid receptor affinity. These compounds proved to be selective CB1 cannabinoid receptor ligands, acting as inverse agonists in a [35S]-GTPgammaS assay. The affinity of 3,5,5'-triphenylimidazolidine-2,4-dione and 3,5,5'-triphenyl-2-thioxoim...