Malignant gliomas are highly resistant to current therapeutic approaches due to genetic alterations rendering them resistant to cell death. CK2, a ubiquitous and constitutively active serine/threonine kinase, frequently elevated in tumors, contributes to enhanced cell proliferation and resistance to apoptosis. Inhibition of CK2 expression or treatment with inhibitors of CK2 affected survival or...

The chemistry and nature of biochars are still far from being well understood. In the present work, solid-state 2D HETCOR 1H-13C NMR spectroscopy is introduced for an improved characterization aromatic network in biochars. To that end, a pyrochar obtained pyrolysis cellulose at 350 °C 1 h was used as example. Variation contact time during cross polarization 50 µs, to 200 µs 1000 gave informatio...

A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there...

Pyrene and its derivatives exhibit thermal stability, high extinction coefficients, excimer formation, high photoluminescence, long fluorescence lifetime, fluorophoric properties and enhanced charge carrier mobility which make them find applications in optoelectronic area and are useful as large planar synthetic building blocks in supramolecular chemistry. One of the approaches to overcome this...

complexes of the type (och2c(ch3)2ch2ob)2s2p(s)or (where r=me,et,pri,bui,ph,ch2ph) have beensynthesized by the reactions of 2-chloro-1,3,2-dioxaborinanes and potassium salt of o-alkyl (o-aryl)trithiophosphates in 2:1 molar ratio in refluxing benzene. the product are formed as white or light yellowcoloured monomeric solid, soluble in common organic solvents and exhibit high sensitivity towardsat...

Condensation of 1-(9-alkyl-9H-carbazol-3-yl)-4-carboxy-2-pyrrolidinones with 2,3-diaminonaphthalene or o-aminophenol was carried out by melting a reaction mixture at 170–230 °C and provided new 2-substituted naphtho[2,3-d]imidazole and benzoxazole derivatives. Derivatives of 2-substituted naphtho[2,3d]imidazole were alkylated with an excess of ethyl iodide in the presence of potassium hydroxide...

Three water-soluble N-alkyl ammonium resorcinarene chlorides decorated with terminal hydroxyl groups at the lower rims were synthesized and characterized. The receptors were decorated at the upper rim with either terminal hydroxyl, rigid cyclohexyl, or flexible benzyl groups. The binding affinities of these receptors toward three viologen derivatives, two of which possess an acetylmethyl group ...

Octyl- and nonylphenols in the environment have been proposed to function as estrogens. To gain insight into their structural essentials in binding to the estrogen receptor, a series of phenols with saturated alkyl groups at the para position, HO-C6H4-CnH2n+1 (n = 0-12), were examined for their ability to displace [3H]17beta-estradiol in the recombinant human estrogen receptor, which was expres...

A series of 3-deazapurine ribonucleosides 5a–5l bearing diverse C-substituents (alkyl, aryl and heteroaryl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of either free 6-chloro-3-deazapurine ribonucleoside 4 or its acetyl protected congener 3 followed by deprotection. An improved synthesis of the starting 4-chloro-1-(2,3,5-tri-O-acetylβ-D-ribofuranosyl)-1H-imidazo[4,...