Objective: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  The aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (TNF-α),  interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (P...

Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...

A 12-week nutritional research was conducted to evaluate the influences of benfotiamine on growth performance, oxidative stress, inflammation and apoptosis in Megalobrama amblycephala (45.25 ± 0.34 g) fed high-carbohydrate (HC) diets. Six diets were prepared, containing control diet (30% carbohydrate, C), HC (43% carbohydrate) supplemented with four levels (0.7125 (HCB1), 1.425 (HCB2), 2.85 (HC...

background and aims: kindling is regarded as an experimental model of temporal lobe epilepsy that reflects a process of progressive and persistent intensification of seizure. experimental and clinical evidence suggest that there is an interrelationship among epileptogenesis, local inflammation and antioxidant activity. in this study, the possible antioxidant and anti-inflammatory effects of thy...

Background: Hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. We previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) modulates epileptogenesis in rats. There is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. Gap junction channels are formed ...

Background Gout is a chronic inflammatory disease featuring the deposition of monosodium urate (MSU) crystals in synovial fluid patients, followed by NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome activation bioactive IL-1β release, which recruits neutrophils to local inflammation sites. Blocking function becoming potent therapeutic approach for gout gouty arthritis. Conv...

Tribological performance of polyalphaolefin 32, PAO, is investigated by adding two nanomaterials (graphene nanoplatelets, GnP, and hexagonal boron nitride nanoparticles, h-BN) an ionic liquid ([P 6,6,6,14 ][DEHP], IL1, [P 2,4,4,4 ][DEP], IL2, or ][(iC8) 2 PO ], IL3). Designed double hybrid nanodispersions are PAO/1 wt% ILX/0.05 GnP/0.1 h-BN (X = 1, 3). The best anti-friction behavior correspond...