Leishmania donovani Suppresses Activated Protein 1 and NFB Activation in Host Macrophages via Ceramide Generation: Involvement of Extracellular Signal-Regulated Kinase Sanjukta Ghosh, Sandip Bhattacharyya, Madhumita Sirkar, Gouri Shankar Sa, Tanya Das, Debashis Majumdar, Syamal Roy, and Subrata Majumdar* Department of Microbiology and Department of Animal Physiology, Bose Institute, Calcutta 70...

Background: Responsive Neurostimulation (RNS) has proven efficacy in the treatment of medically resistant epilepsy as an intracranial system that detects, records and treats seizures automatically. No information exists pertaining to artifact characteristics RNS findings scalp EEG. Methods: A 30 year-old female was diagnosed, using electroencephalography (iEEG), with refractory bi-insular epile...

L. PANIGRAHI*, S. K. GHOSAL, SNIGDHA PATTNAIK, L. MAHARANA AND B. B. BARIK School of Pharmaceutical Sciences, I. T. E. R., Jagamohan Nagar, Gagamara, Bhubaneswar-751 030, *Sun Pharma Advance Rearch Center, Tandalja, Vadodara-390 020, Pharmaceutical Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700 032, University Department of Pharmaceutical Science...

We present the first V I CCD photometry for the Sculptor group galaxy ESO 540-032 obtained at the Very Large Telescope UT1+FORS1. The (I, V − I) colour-magnitude diagram indicates that this intermediatetype dwarf galaxy is dominated by old, metal-poor ([Fe/H]≈ −1.7 dex) stars, with a small population of slightly more metal-rich ([Fe/H]≈ −1.3 dex), young (age 150 − 500 Myr) stars. A discontinuit...

BACKGROUND Schizophrenia typically onsets after puberty but is often preceded by observable childhood neurodevelopmental impairments. Whether these childhood antecedents index genetic liability is unknown. We used polygenic risk scores derived from a patient discovery sample as indicators of the genetic liability of schizophrenia. Our aim was to identify the early childhood manifestations of th...

AIMS The success in achieving treatment goals for cardiovascular risk factors in primary care is largely unknown. Therefore, the goals of this study were (i) to assess whether routinely collected practice data can be used to evaluate treatment in primary care, (ii) to compare current treatment with goals of published guidelines, and (iii) to calculate future risk for cardiovascular events using...