We investigated the immunogenicity of spesolimab, and its impact on PK, efficacy, safety in patients with a GPP flare. Plasma samples were analysed from three trials. In trial 1 (proof concept, NCT02978690), 7 received IV spesolimab 10 mg/kg. 2 (Effisayil 1, NCT03782792), 53 randomised 2:1 to receive 900 mg or placebo Day optional open-label (OL) 8 for persistent flare symptoms. At Week 12, cou...

With ablation using a saline flow catheter tips, occasionally microbubbles will be seen, either from excessive heating or steam pops. The occurrence and implications of microbubble formation with PFA/IRE has not been determined. This study aim was to clarify the means during ablation. Therefore, total 4 dogs underwent evaluation delivery 34 ablated lesions in right left atrium. During ablation,...

Recent studies have implicated monocytes/macrophages play important roles in the pathogenesis of systemic sclerosis (SSc). We previously reported levels circulating periostin were increased SSc, and it was positively correlated with modified Rodnan's total skin thickness score (mRSS). Therefore, we focused on effect monocytes monocyte-derived macrophages (MDM) SSc. Monocytes purified from blood...