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Background: Epileptic spasms (ES) are a devastating seizure type with poor neurodevelopmental outcome; 1/3 resistant to treatment first line therapies. Recently attention has been drawn the ketogenic diet (KD) as potentially effective therapy, though data regarding optimal time of initiation, and its sustained effectiveness, lacking. Methods: Retrospective chart review all patients ES treated K...

Introduction: Targeting ubiquitin-proteasome system (UPS) has emerged as a rational approach in the treatment of human cancer. The therapeutic potential this pathway been validated by clinical successes bortezomib – first proteasome inhibitor drug implemented therapy multiple myeloma and mantle cell lymphoma. However, solid tumors remains challenging, mostly due to poor tumor-selective delivery...

jahez is one m of the most prominent character in the field of science and literature in the world.in addition to his proficiency in sciences,education and literature,he is one of the most celebrated one in discourse science and beliefs.he innovated a new religion called “jahezie religion’’ in the history of discourse  cience.from among his important works which are famous in all over the world...