BACKGROUND Fatigue, cognitive deficits, and depression are frequently reported but often undertreated symptoms that can profoundly affect daily life in patients with primary brain tumors (PBTs). To evaluate the effects of the psychostimulant modafinil on fatigue, depression, health-related quality of life (HRQOL), and cognitive functioning in PBT patients, we performed a multicenter, double-bli...

OBJECTIVE To estimate the risks of anaesthetic and sedation-related mortality in companion animals in the UK. (The Confidential Enquiry into Perioperative Small Animal Fatalities, CEPSAF). STUDY DESIGN A prospective cohort study with nested case-control study. ANIMAL POPULATION All small animals anaesthetized and sedated at participating centres between June 2002 and June 2004. METHODS Pa...

The increasingly widespread use of mobile phone applications (apps) as research tools and cost-effective means of vast data collection raises new methodological challenges. In recent years, it has become a common practice for scientists to design apps that run only on a single operating system, thereby excluding large numbers of users who use a different operating system. However, empirical evi...

Abstract The rarest posterior abdominal wall defect with retro and intra peritoneal contents through the upper lumbar posterolateral associated weakening of triangle is grynfeltt -lesshaft hernia. Lumbar hernia initially small asymptomatic expands over time may lead to mild symptoms gradually leading definitely grave complications. Grenynfeltt –lesshaft quite often missed due unfamiliar nature ...

Methamphetamine (METH) is a psychostimulant drug of abuse that produces long-term behavioral changes including behavioral sensitization, tolerance, and dependence. METH has been reported to induce neurotoxic effects in several areas of the brain via the dopaminergic system. Changes of dopamine function can induce malfunction of the glutamatergic system. Therefore, the aim of the present study w...

BACKGROUND Emergent coronary artery bypass grafting (CABG) surgery is often required in the case of severe coronary artery disease, which is refractory to traditional management. The objective of our study was to test the hypothesis that there is seasonal variation in the incidence of emergent CABG. METHODS A sinusoidal logistic regression model was used to analyze operative data at our cardi...