BACKGROUND Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase-2 (COX-2) expression observed during tumorigenesis and metastasis. METHODS To assess the correlation between COX-2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX-2 were assessed via immunohistochemistry analyses...

We formulate separating equilibria with (many) signals as the set of zeroes of a suitable mapping and show continuity of this mapping for a suitable topolm We prove upper semi-continuity (USC) of the correspondence mapping the set of multidimensional signalling environments into their sets of separating equilibria. Journal of Economic Literature Classification Numbers: 022, 026.

The M1 muscarine agonist, 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2, 3,6-tetrahydropyridine (Lu 25-109), is extensively metabolized in mice, rats, dogs, and humans. The metabolite profile after an oral dose of [(14)C]Lu 25-109 was determined in plasma and in urine. Lu 25-109 was metabolized by N-demethylation (Lu 25-077), N-oxidation (Lu 32-181), and N-deethylation (Lu 31-126). In addition, com...

In this paper, on-chip test circuitry performing the transient supply current measurement is presented. The introduced principle makes uses of the parasitic resistance of the supply connection to sense the dynamic supply current. Thus, the monitor does not cause any additional power supply voltage degradation and provides detection capabilities for open defects that usually cause a significant ...

Methods All exons of NLRP3 were amplified by PCR (30 cycles) from genomic DNA isolated from PBMCs of healthy controls or CAPS patients. Thereafter, PCR products were concatenated, fragmented and subjected to NGS fragment library preparation followed by Illumina short read sequencing. For SNV calling a customized pipeline on basis of the GATK pipeline (1000 Genomes project) was utilized using a ...

Abstract Study question What is the effectiveness and safety of various follicular phase ovarian stimulation protocols for intrauterine insemination (IUI) performed any indication? Summary answer Significantly higher LBR/OPR was noted gonadotrophins versus oral agents. Clomiphene+estrogen gonadotrophins+letrozole demonstrated significantly OPR/LBR compared to no stimulation/stimulation with age...