Anti-cancer drugs are an important class of pharmaceutical products. Methotrexate (MTX) is a folic acid antagonist used in high doses as antimetabolite in anti-cancer treatment as well as in low doses for the treatment of rheumatoid arthritis and adults' psoriasis. In the past, several anti-cancer drugs, including methotrexate, have been found in the environment. Their presence in water, especi...

Abstract This study experimentally demonstrates the potential of co-chlorination as a green process alternative to conventional independent chlorination polyolefins, which involves use non-environment-friendly solvents like carbon tetrachloride (CCl 4 ). Low-density polyethylene (LDPE) was used representative polymer in this and co-chlorinated with paraffin. Apart from being reactant, paraffin ...

A kinetic model of hydrolysis, chlorination and dehydrochlorination involving epichlorohydrin glycidol, covering a broad range temperature pH, was developed.

We present here a computational study of reactions at a model complex of the SyrB2 enzyme active site. SyrB2, which chlorinates L-threonine in the syringomycin biosynthetic pathway, belongs to a recently discovered class of alpha-ketoglutarate (alphaKG), non-heme Fe(II)-dependent halogenases that share many structural and chemical similarities with hydroxylases. Namely, halogenases and hydroxyl...

This paper presents three new approaches to reduce excess sludge production in activated sludge systems: 1) modification of conventional activated sludge process with insertion of a sludge holding tank in the sludge return line; 2) chlorination of excess sludge so as to minimize excess sludge production; and 3) utilization of a metabolic uncoupler, 3, 3', 4', 5-Tetrachlorosalicylanilide (TCS) t...

Introduction of chlorine into aromatic rings by electrophilic substitution is an important synthetic transformation because chlorinated hydrocarbons are recognized as versatile starting materials and additives in th e p rod uctio n o f h igh qu ality in sectic ides, fungicides, herbicides, dyes, pharmaceuticals 1 Moreover, they can serve as precursors for numerous functionalities, such as pheno...

Deteriorating water treatment facilities and distribution systems pose a significant public health threat, particularly in republics of the former Soviet Union. Interventions to decrease the disease burden associated with these water systems range from upgrading distribution networks to installing reverse osmosis technology. To provide insight into this decision process, we conducted a randomiz...

The introduction of chlorine atoms into organic molecules is fundamental to the manufacture industrial chemicals, elaboration advanced synthetic intermediates and also fine-tuning physicochemical biological properties drugs, agrochemicals polymers. We report here a general practical photochemical strategy enabling site-selective chlorination sp3 C?H bonds. This process exploits ability protonat...