The effects of sulfonylureas on the production of plasminogen activator (PA) and antiactivator (PAI) were investigated using bovine aortic endothelial cells. All compounds studied stimulated PA release (1.3- to 5.2-fold), with glipizide being the most potent, followed by tolazamide, chlorpropamide, and tolbutamide, in that order, while glyburide was the least effective. Both tissue-type and uro...

Another point to consider is whether treatment of diabetes could have played a significant part in the aetiology of renal agenesis. The critical time for renal development is between 3 and 7 weeks, the somite stage to 18 mm size. During this time the mesonephros, mesonephric duct, metanephros and ureteric bud are in an active stage of development (Shikinami, 1926; Torrey, 1954). Hypoglycaemia h...

The effect of several hypoglycemic sulphonylureas upon the oxidative phosphorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide wer...