Immunosuppressive therapies are indicated following liver transplantation (LT) to prevent graft loss through rejection, and these same agents also may have a role in the management of inflammatory bowel disease (IBD). The aims of this study were to examine the effects of immunosuppression following LT on IBD activity and to identify markers of IBD control post-LT in patients with IBD who underw...

Growth of solid fibrosarcoma tumors in mice was inhibited by the release of a soluble lymphotoxinreceptor inhibitor (LT R-immunoglobulin fusion protein) from the tumor cells. Tumor growth arrest in mice deficient in the ligand LT 1 2 demonstrated the requirement for activation of the LT R on the tumor cells by host cell-derived LT 1 2. Activation of the LT R resulted in enhanced release of macr...

BACKGROUND Liver transplantation (LT) increases the risk of de novo malignancies including skin cancers. However, risk factors for this type of cancers have not been well studied. OBJECTIVE To determine the incidence of skin cancer in LT recipients, and to identify the risk factors of this type of cancer. METHODS We identified all adult patients who underwent LT and developed de novo skin c...

UNLABELLED Background. Thyroid hormones are the most important factors involved in the regulation of the basal metabolic condition, as well as in the oxidative metabolism. Hypothyroidism is associated with increased cardiovascular morbidity, which cannot be fully explained by the atherogenic lipid profile observed in these patients. AIM Study of serum lipids, tHcy, hs-CRP, MDA and PON-1 level...

Escherichia coli heat-labile enterotoxin (LT) bound to rat glioma C6 cells that had incorporated ganglioside GMl but not to cells that had taken up gangliosides GM2, GD~, or G D ~ ~ . The same specificity also was observed with choleragen, the enterotoxin of Vihrio cholem. The tryptophanyl fluorescence spectra of LT and its B component differed from those of choleragen and its B component, resp...

To understand the meaning of the lactate threshold (LT) and to test the hypothesis that endurance training augments lactate kinetics [i.e., rates of appearance and disposal (Ra and Rd, respectively, mg·kg(-1)·min(-1)) and metabolic clearance rate (MCR, ml·kg(-1)·min(-1))], we studied six untrained (UT) and six trained (T) subjects during 60-min exercise bouts at power outputs (PO) eliciting the...

TNF, lymphotoxin (LT)-alpha, LT-beta and LIGHT are members of a larger superfamily of TNF-related cytokines that can cross-utilize several receptors. Although LIGHT has been implicated in thymic development and function, the role of TNF and LT remains incompletely defined. To address this, we created a model of modest homeostatic overexpression of TNF/LT cytokines using the genomic human TNF/LT...

Light therapy (LT) has been widely used in the treatment of seasonal affective disorder. Recently some evidence indicated that LT may play a role in bipolar depression, either as monotherapy or in combination with total sleep deprivation (TSD). However, the studies examining the treatment effect of LT in bipolar depression resulted in inconsistent findings. To clarify the role of LT in the diso...

Patients with hepatocellular carcinoma (HCC) satisfying the Milan criteria are candidates for liver transplantation (LT), but locoregional therapies could be another options for them.A total of 1859 treatment-naïve HCC patients fulfilling the Milan criteria were analyzed. Survival tree analysis was performed to generate survival nodes with similar survival risks in 1729 non-LT group, and compar...

Merkel cell polyomavirus (MCV) is clonally integrated in over 80 % of Merkel cell carcinomas and mediates tumour development through the expression of viral oncoproteins, the large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T-antigen locus that result in deletions of C-terminal replicative functions of the LT antigen. Despite these truncati...