Because codeine (COD) is eliminated primarily via glucuronidation, factors that alter COD glucuronide formation potentially affect the proportion of the dose converted to the pharmacologically active metabolite morphine. Thus, in vitro-in vivo extrapolation approaches were used to identify potential drug-drug interactions arising from inhibition of COD glucuronidation in humans. Initial studies...

In this study, we investigated the efficiency of dissolved methane (D-CH(4)) collection by degasification from the effluent of a bench-scale upflow anaerobic sludge blanket (UASB) reactor treating synthetic wastewater. A hollow-fiber degassing membrane module was used for degasification. This module was connected to the liquid outlet of the UASB reactor. After chemical oxygen demand (COD) remov...

DNA vaccines are administered in the form of plasmid DNA (pDNA) carrying a strong promoter and the gene of interest. In this study we investigated the tissue distribution, cellular uptake and the fate of intravenously (i.v.) and intramuscularly (i.m.) injected pDNA in Atlantic cod (Gadus morhua L.). The anatomical distribution of pDNA was determined using both morphological and radiotracing met...

Educational ontologies are classified into οnthologies of Student Learning Outcomes (SLO), Learning Objects (LO) and Cognitive Domains (CoD). In contrast to the conceptualization and implementation of SLO and LO ontologies, based on standards available in the literature, the CoD ontologies involve subjectivity derived from the analysis of basic concepts of each CoD and relational expressions th...

We relate two diierent approaches for the speciication and veriication of hybrid systems. The rst one is logic-based and uses the framework of the Calculus of Durations (CoD), the second one is automata-based and uses algorithmic analysis techniques for hybrid automata. Fragments of CoD have been identiied in 13, 19] for the description of control systems and their requirements. We mainly show ...

The behavioural response of cod (Gadus morhua) to sudden pressure reductions was investigated in a large electronic-tagging experiment using data collected from 141 cod tagged in five different areas of the Northeast Atlantic. More than 40% of cod exhibited a characteristic equilibration behaviour after a rapid pressure reduction caused either by capture before tagging, or by pressure reduction...