background: the vegf is essential in the process of tissue remodeling and angiogenesis. limited data is available on the expression and regulation of vegf and its receptors in the human endometrium. the aim of this study was evaluation of expression patterns of vegf and flk-1 in human endometrium during the menstrual cycle. methods: sixty paraffin-embedded blocks of endometrial tissues from the...

conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of people living type 1 and 2 diabetes mellitus developing DKD. Upregulation vascular endothelial growth factor (VEGF) in the is significant pathology DKD associated increased glomerular permeability. To date, however, current anti-VEGF therapies have demonstrated limited success treating Recent studies shown that ...

Glioblastoma (GBM) is one of the most highly vascularized human cancers. The role exosomes in cancer angiogenesis has attracted recent interest. However, proangiogenic biomolecules transported by to facilitate GBM have not yet been identified. Here, we found a specific 120-kDa isoform vascular endothelial growth factor (VEGF) GBM-derived and confirmed it as VEGF-C. By binding VEGF receptor 2 (V...

background: henoch-schönlein purpura (hsp) is an lga mediated small vessel systemic vasculitis disease in children. the etiology and pathogenesis of hsp disease remain unknown. however, environmental and genetic risk factors could play important roles in susceptibility to hsp disease. in this study we investigated the association of 5՛-untranslated region polymorphism (-634g/c) of vegf gene wit...

background and aims. vascular endothelial growth factor (vegf) and ki-67 antigen are contributing factors in this process cell proliferation and new blood vessels formation in tumor progression. this study was conducted to examine the relationship between the expression of vegf and ki-67 and gender and age of patients with oral squamous cell carcinoma (oscc). materials and methods. twenty-three...

conclusions vpa and cbz treatments caused a decrease in β-catenin and vegf levels in sw480 colon cancer cell lines. these results suggest that cbz can be considered a potential antitumor drug with potencies different from vpa. methods in the present experimental study, implemented during 2014 - 2015 in iran, after incubation of cells into 96-well plates with 5,500 cells/well, the tested drugs w...