Introduction: ALK-negative anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell neoplasm which can sometimes harbour DUSP22 rearrangement (DUSP22-R) on 6p25.3. In the first clinical report, 5-year OS of 22 patients with DUSP22-R was 90% (Parrilla Castellar et al, Blood 2014). However, in later work from British Columbia Cancer Lymphoid database, 12 40% (Hapgood BJH 2019). Thus, prognostic im...

Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developm...

2 Exercise. Prove it. ◦ In fact, as sophisticates can show you, on a complex space a linear operator which preserves all norms will also preserve all inner products. But the key thing is to remember is that a unitary operator preserves all inner products (and therefore all norms). • This is analogous to the fact that translations and rotations in ordinary three-dimensional space preserve distan...

Apoptosis of testicular germ cells during fetal development is regulated by both p53-dependent and independent mechanisms. However, its precise mechanisms are largely unknown. A member of p53 gene family, p63, is required for p53-dependent apoptosis and can induce apoptosis in the absence of p53 through the activation of p53-target genes. In this study, we examined the expression pattern of p63...

A combination of 100 mg/ml of ketamine hydrochloride (Ket) and 20 mg/ml of xylazine hydrochloride (Xyl) was used to immobilize coypus (Myocastor coypus). Eight mature coypus (four males and four females) were injected intramuscularly with doses ranging from 2.33 to 6.25 mg/kg of KET and 0.25 to 0.86 mg/kg of Xyl. The mean (+/- SE) time for induction, arousal, and recovery were 7.3 +/- 2 min, 23...