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تعداد نتایج: 16597 فیلتر نتایج به سال:
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but the basis for these characteristics remains unknown. In this study, we show that upregulation of the Polycomb protein histone methyltransferase EZH2, which limits differentiation in many tissues, is critical to maintain the undifferentiated state and poor pr...
Melanocytes are derived from neural crest cells, which also differentiate into neurons, glial bone/cartilage and smooth muscles. Melanocyte-inducing transcription factor (MITF) promotes melanocyte development differentiation through activating pigment genes. Since MITF activates most of its target genes represses a few them, we aimed to characterize repressed by MITF. By using RNA sequencing ch...
Epidemiologic, clinical and experimental data indicates that a majority of brain disorders including schizophrenia (SCZ), posttraumatic stress disorder (PTSD), and ischemic stroke (IS) are multifactorial disorders with strong and complex genetic component. Identification of all genetic variations associated with these disorders may sufficiently contribute to understanding of their basic pathome...
Alcohol abuse and alcoholism induce brain damage, and, in some cases, neurodegeneration. The pathogenesis of the alcohol-induced injury of the CNS is a complex process in which oxidative stress plays an essential role. Alcohol increases the formation of reactive oxygen species and affects the antioxidant defense system of the brain. It is well known that oxidative stress induces apoptosis in ne...
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