BACKGROUND Spirometry, and in particular forced expiratory volume in the first second (FEV(1)), are standard tools for objective evaluation of asthma. However, FEV(1) does not correlate with symptom scores, and hence its value in the assessment of childhood asthma may be limited. Therefore, some clinicians subjectively assess the presence of curvature in the maximum expiratory flow-volume (MEFV...

Sweet’s syndrome (SS) or acute febrile neutrophilic dermatosis is a rare disorder that often occurs in association with other systemic diseases. The disorder is characterized by development of nonpruritic, painful erythematous plaques with pseudovesicles, occasional pustules and rare bullae. SS consists of a triad of erythematous plaques infiltrated by neutrophils in association with fever and ...

Medical staff working in a nasopharyngeal swab sampling cabin are exposed to higher exposure risk of COVID-19. In this study, computational fluid dynamics (CFD) used evaluate the medical Chinese customs under four different ventilation strategies, i.e., multiple supply fans (MSFV), exhaust (MEFV), single fan and outer windows closed (SEFV), opened (SEFV-W). The impact physical partitions on is ...

Objective: It has been suggested that Mediterranean fever (MEFV) gene mutations are also seen in certain autoimmune diseases and are related to severity of the disease activity. As most of the clinical symptoms of these inflammatory diseases are related to autoantibody positivity, we assessed autoantibody prevalence in patients with Familial Mediterranean fever (FMF) and investigated the relati...

The maximal expiratory flow-volume (MEFV) maneuver is a commonly used test of lung function. More detailed interpretation than is currently available might be useful to understand disease better. We propose that a previously published computational model (Lambert RK, Wilson TA, Hyatt RE, and Rodarte JR. J Appl Physiol 52: 44-56, 1982) can be used to deduce, from the MEFV curve, the serial distr...

Pulmonary function tests were performed on 252 healthy young subjects free from respiratory and allergic symptoms, and 80 young subjects with past history of nasal allergy (PNA) and 10 subjects with past history of bronchial asthma (PBA). All the subjects were non-smokers. Maximal expiratory flow-volume (MEFV) curves were visually classified into five types (A-E). The percent distribution of ty...

INTRODUCTION Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent self-limiting fever and serositis that mainly affects Mediterranean populations. Many patients with FMF have been reported in Japan due to increasing recognition of this condition and the availability of genetic analysis for the gene responsible, MEFV. The present study was perfor...

BACKGROUND Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent attacks of fever and serositis. Amyloidosis is the most significant complication of FMF, leading to end stage renal disease (ESRD). Recently the gene (MEFV) causing this disease was cloned and more than 18 mutations have been identified. The hypothesis that the development of amyloidosis i...

Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were drawn for young male nonsmoking healthy adults and for young male nonsmoking asthmatic patients. Eleven parameters, two MEVT (%FVC and FEV1.0%), six MEFV (PFR, V75, V50, V25, V10 and V50/V25), and three MTC parameters (MTC75-50, MTC50-25 and MTC25-RV) were used for the multivariate analysis. The multivariate analysis in ...

Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder with more than 60 disease-associated mutations in the responsible gene, MEFV. In the present study, we determined 15 MEFV mutations in Iranian Azeri Turkish FMF patients. Five hundred and twenty-four unrelated patients were tested for 15 known mutations in the MEFV gene using amplification refractory mutation...