OBJECTIVES To investigate the frequency of the growth hormone receptor (GHR)-d3 polymorphism in a random sample of Saudi Arabian population from Jazan province, and test the effects of the polymorphism on some anthropometric factors. METHODS This cross-sectional population-based study was conducted during the period from January to April 2017 at the College of Applied Medical Sciences, Jazan ...

CONTEXT There is great interindividual variability in the response to recombinant human (rh) GH therapy in patients with Turner syndrome (TS). Ascertaining genetic factors can improve the accuracy of growth response predictions. OBJECTIVE The objective of the study was to assess the individual and combined influence of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on the short- and long-term o...

Growth hormone (GH), acting through its receptor (GHR), is essential for somatic growth and development and maintaining metabolic homeostasis. GHR gene-deficient (GHR(-/-)) mice exhibit drastically diminished insulin-like growth factor-I (IGF-I) levels, proportional growth retardation, elevated insulin sensitivity, and reduced islet beta-cell mass. Unlike the liver, which is mostly unaffected b...

the growth hormone (gh) gene is a candidate for growth trait in farm animals and plays an important role in growth metabolism. growth hormone can contribute in growth metabolism when it's receptor (ghr) are on cells target. the single nucleotide polymorphism was occurred in gh and ghr genes and that associated with carcass traits in lori-bakhtiari sheep breed with using pcr-sscp. in this r...

The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in theGHR...

Alleles of physiological candidate genes for reproductive traits, insulin-like growth factor-1 (IGF-1), and growth hormone receptor (GHR) were assessed to determine their associations with total egg production (NE), average days of continual egg-laying (ADCE), and number of double yolk eggs (DYE) in Wenchang chickens (Chinese indigenous breed). PCR-RFLP was used for genotype identification. The...

Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were shown to regulate life span in lower organisms, the role of GH signaling in human longevity remains unclear. Because a GH receptor exon 3 deletion (d3-GHR) appears to modulate GH sensitivity in humans, we hypothesized that this polymorphism could play a role in human longevity. We report a linear increased...

Forhead, A. J., J. Li, J. C. Saunders, M. J. Dauncey, R. S. Gilmour, and A. L. Fowden. Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero. Am J Physiol Endocrinol Metab 278: E1166–E1174, 2000.—By use of RNase protection assays, hepatic growth hormone receptor (GHR) and insulinlike growth factor I (IGF-I) mRNA abundances were measured i...

The functional role of the exon 3 growth hormone receptor (d3GHR) polymorphism in human and its distributions in different populations is not clearly understood. The presence of full length growth hormone (flGHR) is the most important in metabolic risk factors. The aim of this study was to define the frequency distribution of d3GHR/full-length GHR in an Iranian population. The presence of the d...