In this paper we cluster data from protein networks and integrate the results with chemical databases and ontologies to investigate functional links between related disease states. It is well know that certain genes participate in more than one function and if they are defective are likely to be responsible for several health problems. Furthermore, genes tend to cooperate in associated networks...

Nephropathic cystinosis is a lysosomal disorder caused by functional defects of cystinosin, which mediates cystine efflux into the cytosol. The protein sequence contains at least two signals that target the protein to the lysosomal compartment, one of which is located at the carboxy terminal tail (GYDQL). We have isolated from a human kidney cDNA library a cystinosin isoform, which is generated...

Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3'-deoxy-3'-18F-fluorothymidine (18F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume (TV) changes. Tumor bearing nude mice were assigned to either irradiated daily or every second day group and then randomized t...

BACKGROUND AND OBJECTIVES Cystinosis is an autosomal recessive disease characterized by the intralysosomal accumulation of cystine, as a result of a defect in cystine transport across the lysosomal membrane. Three clinical forms have been described on the basis of severity of symptoms and age of onset: infantile cystinosis, characterized by renal proximal tubulopathy and progression to end-stag...

Cystinosis is a rare autosomal recessive disorder characterized by the intralysosomal accumulation of cystine in all tissues due to mutations in the CTNS gene (17p13.3). Infantile nephropatic cystinosis is the most severe and the most frequent form of the disease. It causes renal Fanconi syndrome, leading to end stage renal failure around the age of 10 years if left untreated. Cystine accumulat...

Foreign DNA elements such as plasmids and conjugative transposons are constantly entering new bacterial hosts. A possible outcome of such events that has not been considered previously is that regulatory genes carried on some of them might affect the expression of chromosomal genes of the new host. To assess this possibility, we investigated the effect of the Bacteroides conjugative transposon ...

Arboreal mammals form a diverse group providing ecologically important functions such as predation, pollination and seed dispersal. However, their cryptic elusive nature, the heights at which they live, makes studying these species challenging. Consequently, our knowledge of rainforest is heavily biased towards terrestrial species, limiting understanding overall community structure possible imp...

To provide security in data communication networks various forms of cryptographic and steganographic algorithms have been proposed. Though both of these techniques serve the same purpose i.e. to secure data but have some drawbacks. Using cryptography might raise some suspicion whereas in steganography the distortion in cover can attract an adversary. The combinations of the two as proposed by v...