Introduction: Diffuse Large B- cell Lymphoma (DLBCL) is characterized by genetic and clinical heterogeneity. Different loci within the human leukocyte antigen (HLA) region have been implicated in susceptibility disease control of DLBCL. Methods: HLA typing was performed using Sequence-Specific Oligonucleotide (SSO) Primer (SSP) 60 DLBCL patients 250 healthy adult donors from local Bone Marrow r...

Background: Autoimmune blistering diseases (AIBDs) are a group of rare acquired skin diseases, which divided into five major subtypes based on the clinical appearance and pathology: pemphigus bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA), dermatitis herpetiformis (DH) Linear IgA dermatosis (LigA). Current understanding has been greatly increased by genetic investigations mainly...

Hepatitis C virus (HCV) is a major public health problem with more than 130-180 million people infected worldwide. Several studies in different populations have reported the association of human leukocyte antigen (HLA) genotypes, and HCV viral load, and genotypes. The aim of this study was to investigate a possible association between HLA class I and II alleles in HCV-infected patients and heal...

hla-g is normally expressed on human trophoblast cells. it is a non-classical mhc molecule class i b. the role of hla-g in diabetic type 1 is not known. we investigated the role of ifn-β in induction hla-g expression on the monocyte derived dendritic cells (dc) in diabetes type 1. treatment of dendritic cell with ifn-β in vitro from diabetic patients (n=20) and normal subjects (n=20) resulted t...

previous studies have demonstrated some significant differences in hla allele frequencies in leukemic patients and normal subjects. we have analyzed hla class ii alleles and haplotypes in 60 iranian patients with acute myelogenous leukemia (aml) and 180 unrelated normal subjects. blood samples were collected after obtaining informed consents. from the patients and control dna extraction and hla...

HLA class I and KIR sequences were determined for Dogon, Fulani, Baka populations of western Africa, Mbuti central Datooga, Iraqw, Hadza eastern Africa. Study 162 individuals identified 134 alleles (41 HLA-A, 60 HLA-B, 33 HLA-C). Common to all are three HLA-C (C1+C*07:01, C1+C*07:02, C2+C*06:02) but ...

【背景】HLA抗体による血小板輸血不応症例には，HLA適合血小板（PC-HLA）が推奨される．ドナーの選定には，HLA-A座，B座の適合性を確認するが，HLA-C座の適合性は優先されない．本研究では，HLA-C座の適合性による輸血効果を解析した．【方法】関東甲信越ブロックにおいてHLA-C抗体による交差適合試験陽性例の輸血効果を解析した．また，東京大学医学部附属病院においてHLA抗体を保有する血小板輸血不応患者1例に対してPC-HLA（66本），適合血小板（19本）およびランダムの血小板製剤（7本）について，輸血効果を評価し，後追いの交差適合試験を実施した．【結果】交差適合試験陽性57件（陽性率0.25%）のうちHLA-C抗体によるものは27件（47.4％）であり，Cw8抗体が55.0%を占めていた．HLA-C座不一致製剤の75％は有効であった．東大01症例はCw15抗体陽性かつCw...

Objective To better characterize the genetic association between human leukocyte antigen (HLA) and anti-IgLON5 disease to explore auto-antigen binding associated HLA molecules their functional involvement in pathophysiology. Background Anti-IgLON5 is a rare, but likely underdiagnosed type of autoantibody encephalitis with heterogeneous clinical phenotype, including sleep, movement brainstem dys...