As a world superpower, the United States has very stable exchange rate and big impact on currencies of other countries, like Indonesia. Probability modeling is therefore essential for analyzing change in rates between Indonesian rupiah (IDR) US dollar (USD). In addition to comparing distributions two parameters, this study also discusses use several mixture 2 3 component distribution probabilit...

Genetic testing for cardiac channelopathies such as long QT syndrome (LQTS) and Brugada (BrS) is standard of care. Although the American College Medical Genetics (ACMG) guidelines variant interpretation have provided a framework distinguishing pathogenic variants from benign, many rare genetic remain classified uncertain significance (VUS) due to lack epidemiologic or functional data either pro...

Essentials Recently, ADAMTS-13 has been shown to undergo substrate induced conformation activation. Conformational quiescence of ADAMTS-13 may serve to prevent off-target proteolysis in plasma. Conformationally active ADAMTS-13 variants are capable of proteolysing the Aα chain of fibrinogen. This should be considered as ADAMTS-13 variants are developed as potential therapeutic agents. Click to ...

OBJECTIVE Medical classification accuracy studies often yield continuous data based on predictive models for treatment outcomes. A popular method for evaluating the performance of diagnostic tests is the receiver operating characteristic (ROC) curve analysis. The main objective was to develop a global statistical hypothesis test for assessing the goodness-of-fit (GOF) for parametric ROC curves ...

We discuss the prospects of precise specification of design patterns. We analyze the manuscript of the GoF patterns catalog, and prove that the essence of many design patterns can be preserved through the translation to some formal language. Contemporary Means of Specification There is widespread interest in design patterns [GoF 95; Coplien & Schmidt 95; Vlissides, Coplien & Kerth 96; Buschmann...

The maritime traffic in the Gulf of Finland (GoF), North-eastern Baltic Sea, is predicted to rapidly grow in the near future, which increases the environmental risks through both direct environmental effects and by increasing the risk of severe oil accident. A multidisciplinary group of researchers has developed a prototype of risk assessment and decision support model, applying Bayesian Networ...

The Baltic Sea is vulnerable to environmental changes. With the increasing shipping activities, the risk of oil spills remains high. Archaea are widely distributed in many environments. However, the distribution and the response of archaeal communities to oil contamination have rarely been investigated in brackish habitats. Hence, we conducted a survey to investigate the distribution, diversity...

Application of the Minkowski–Bouligand fractal dimension for the differential diagnosis of thyroid follicular neoplasias To the Editor, Nuclear characteristics are important for the differential diagnosis between benign or malignant neo-plasias. Subjective interpretation by an observer, however , may cause diagnostic insecurity [5]. Quantitative morphologic analyses can be helpful in this situa...

Two atomic absorption techniques, acid digestion followed by conventional flame analysis and directanalysisof solidsamples with the graphite furnace, were compared forthe determination of copper in fingernails. Nail samples, from 11 persons, containing between 5 and 50 1zg/gof copper, were analyzed by both methods. There was good correlationbetween resultsofthe two.The furnace requires less sam...