Agent-mediated e-commerce (AMEC) transaction services will be a paradigm shift from the existing client-server e-commerce model. In order to fulfill the leverage of AMEC intermediary services with secure and trusted service capabilities, we propose an agent-oriented public key infrastructure (PKI) operating with a variety of digital certificates. Under this agent-oriented PKI, several trusted A...

The Internet has increasingly been used for communication between people. Most users have no problem relaying messages, which do not contain confidential information, over a network. Yet, for it to be accepted as a medium of conducting monetary transactions there will need to be a higher degree of confidence in the technology’s reliability and security. No one will agree to send his or her fina...

Public key infrastructure (PKI) has emerged as a critical technology for identity management in e-commerce and e-government and over a hundred Certification Authorities across the globe offer certification services. Despite the passing of legislation in many countries to give equal legal weight to electronic signatures as to handwritten ones, the overall market for digital certificates has not ...

In this paper we describe work to expand the PKI for the UK National Grid Service (NGS), to integrate it with site authentication and improve usability. This work is complementary to the UK Shibboleth deployment. As the NGS grows to support wider and larger scientific communities, we investigate how we can improve usability by tying in Virtual Organisation management into the PKI framework.

The digital signature is a key technology in the forthcoming Internet society for electronic healthcare as well as for electronic commerce. Efficient exchanges of authorized information with a digital signature in healthcare information networks require a construction of a public key infrastructure (PKI). In order to introduce a PKI to healthcare information networks in Japan, we proposed a dev...

Although combined chemoradiotherapy has provided considerable improvements for nasopharyngeal carcinoma (NPC), recurrence and metastasis are still frequent. The PI3K/Akt/mTOR pathway plays a critical role in tumor formation and tumor cell survival after radiation-induced DNA damage. In the present study, we evaluated whether inhibition of PI3K/mTOR by two novel dual inhibitors, GSK2126458 and P...

We investigated the hypothesis that cAMP-dependent protein kinase (PKA) protects against endothelial barrier dysfunction in response to proinflammatory mediators. An E1-, E3-, replication-deficient adenovirus (Ad) vector was constructed containing the complete sequence of PKA inhibitor ( PKI) gene (AdPKI). Infection of human microvascular endothelial cells (HMEC) with AdPKI resulted in overexpr...

The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors. The pseudoknot I (PKI) domain of the IRES mimics a tRNA-like codon:anticodon interaction in the ribosomal P site to direct translation initiation from a non-AUG initiation codon in...