Sympathetic stimulation enhances cardiac contractility by stimulating β-adrenergic signaling and protein kinase A (PKA). Recently, phospholemman (PLM) has emerged as an important PKA substrate capable of regulating cytosolic Ca(2+) transients. However, it remains unclear how PLM contributes to β-adrenergic inotropy. Here we developed a computational model to clarify PLM's role in the β-adrenerg...

Phoslactomycins (PLMs), exemplified by PLM B (Figure 1), are a unique class of antitumor, antiviral, and antifungal polyketide natural products.1,2 The antitumor activity of PLMs is attributed to a potent and selective inhibition of protein Ser/Thr phosphatase 2A (PP2A).3 The PLM biosynthetic gene cluster from Streptomyces sp. HK803 has been cloned and sequenced.4 The PLM polyketide synthase (P...

This paper outlines a theoretical model, called the Pattern Lattice Model (PLM) of human linguistic knowledge and performance, and presents a simple implementation of this model. Any expressions found in a natural language L are structured in some ways, and linguists are willing to assume that those expressions are the products of what they call the grammar of L. In contrast, the PLM embodies a...

Innovation is a critical ingredient of today’s organizations. Innovativeness helps organizations to maintain their success and position in the market. Numerous research studies examine the factors that impact successful organizational innovation, for example organizational learning capability, organizational structure, etc. Product Lifecycle Management (PLM) systems have been widely implemented...

In order to improve the performance of extended enterprises, Small and Medium Enterprises (SMEs) must be integrated into the extended networks. This integration must be carried out on several levels which are mastered by the Product Lifecycle Management (PLM). But, PLM is underdeveloped in SMEs mainly because of the difficulties in implementing information systems. This paper aims to propose a ...

Consistent definition, categorization and operationalization of products (e.g. extended products, bundles, etc) delivered to global markets and customized for different buyer segments is one of the major challenges for the Lifecycle Management. Each lifecycle encompasses the processes, information, support systems and people involved in delivering the related business functions. It can be argue...

Candida albicans produces a complex glycosphingolipid called phospholipomannan (PLM), which is present on the cell-wall surface of yeast and shed upon contact with host cells. The glycan moiety of PLM is composed of β-mannosides with degrees of polymerization up to 19 in C. albicans serotype A. PLM from serotype B strains displays a twofold decrease in the length of the glycan chains. In this s...

Post-cuff occlusion flow-mediated dilation (FMD) is a proposed indicator of nitric oxide (NO) bioavailability and vascular function. FMD is reduced in patients with sepsis and may be a marker of end organ damage and mortality. However, FMD likely does not solely reflect NO-mediated vasodilation, is technically challenging, and often demonstrates poor reproducibility. In contrast, passive leg mo...