Objective: The loading of drugs into mesoporous silica (MS) is an effective strategy to improve the solubility poorly water-soluble drugs. Previous reports have stated that surface area and pore volume MS can affect drug its crystallization in MS. Therefore, this study aims elucidate effect size on maximum dissolution profile. Methods: ritonavir (RTV) itraconazole (ITZ) were encapsulated-MS usi...

a ritonavir (RTV)-boosted form is now common. However, randomized data comparing boosted with unboosted PI strategies are scarce. Methods: This randomized, open-label trial compared indinavir (IDV) 800 mg three times daily with IDV/RTV 800/100 mg twice daily, both given with zidovudine (AZT)/lamivudine (3TC) twice daily in individuals with at least 3 months previous AZT experience. The primary ...

OBJECTIVE To examine the usefulness of room temperature vulcanizing (RTV) silicone rubber as a barrier material for cell exclusion zone assays. METHODS We created barriers using three types of RTV silicone rubber with differing viscosities. We then assessed the adherence of these barriers to culture dishes and their ease of removal from the dishes. We tested the effect of the newly created ba...

Background GSK3532795 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor that targets HIV-1 Gag, inhibiting the final protease cleavage between capsid protein p24 and spacer protein-1, producing immature, noninfectious virions. Methods This was a phase 2a, randomized, dose-ranging multipart trial. In part A, subtype B-infected subjects received 5-120 mg GS...

Quantitative microstructural analysis of Room Temperature Vulcanized (RTV) silicone pyrolysis at high temperatures is presented. RTV used as a bonding agent in multiple industries, particularly filling gaps ablative tiles for hypersonic (re-)entry vehicles and fire prevention. Decomposition resolved real time using situ high-temperature X-ray computed micro-tomography. Tomographies are acquired...

AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibi...

Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). Subjects (n = 56) received 600 mg of EFV every 24 h (q24h) for 10 days and rest...

BACKGROUND Twin studies indicate that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) symptoms and reading difficulties (RD) is largely due to shared genetic influences. Both disorders are associated with multiple cognitive impairments, but it remains unclear which cognitive impairments share the aetiological pathway, underlying the co-occurrence of the symptoms. W...

Ceramic insulators are widely used in transmission as well as in distribution lines. As outdoor insulators, the ceramic insulators are subjected to environmental stresses. In particular case, the insulators may severe high pollution exposure. Under the polluted condition, high leakage current will flow on the insulator surface and dry band arching may take place. The phenomena may initiate the ...