نتایج جستجو برای: پروموتر lac

تعداد نتایج: 6311  

2015
Xiang-Yun Ye Qing-Quan Luo Yun-Hua Xu Nai-Wang Tang Xiao-Min Niu Zi-Ming Li Sheng-Ping Shen Shun Lu Zhi-Wei Chen

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate th...

2013
J. Jaime Miranda Victor M. Herrera Julio A. Chirinos Luis F. Gómez Pablo Perel Rafael Pichardo Angel González José R. Sánchez Catterina Ferreccio Ximena Aguilera Eglé Silva Myriam Oróstegui Josefina Medina-Lezama Cynthia M. Pérez Erick Suárez Ana P. Ortiz Luis Rosero Noberto Schapochnik Zulma Ortiz Daniel Ferrante Juan P. Casas Leonelo E. Bautista

BACKGROUND Limited knowledge on the prevalence and distribution of risk factors impairs the planning and implementation of cardiovascular prevention programs in the Latin American and Caribbean (LAC) region. METHODS AND FINDINGS Prevalence of hypertension, diabetes mellitus, abnormal lipoprotein levels, obesity, and smoking were estimated from individual-level patient data pooled from populat...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم بهزیستی و توانبخشی 1389

ناحیه کروموزومی 19p 13.2 دارای پیوستگی پیشنهادی با اختلال اسکیزوافکتیو می باشد. این ناحیه حاوی ژن کلرتیکولین بوده که یک چاپرون پروتئین اندوپلاسمی متصل شونده به کلسیم را کد می کند. بیان وابسته به تکامل و مختص بافت این ژن در ماده خاکستری مغز همزمان با ظهور فنوتیپ پسیکوزها می باشد. ما در سال های اخیر موتاسیون هایی را در ناحیه پروکسیمال پروموتر و توالی کد کننده این ژن در اختلال اسکیزوافکتیو گزارش ک...

2015
Guoming Zhang Song Gao Xiaoyan Li Lulu Zhang Hong Tan Lin Xu Yaoyu Chen Yongjian Geng Yanliang Lin Benjamin Aertker Yuanyuan Sun

This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd, and Lac + Hyd. The left cor...

2014
J. Zhang J. Luo J. Ni L. Tang H.P. Zhang L. Zhang J.F. Xu D. Zheng

Matrix metalloproteinases (MMPs) have been implicated in a variety of pathophysiological conditions, of which MMP-7 is expressed by tumor cells of epithelial and mesenchymal origin. However, the function of MMP-7 in human lung adenocarcinoma (LAC) is unclear. In the present study the expression of MMP-7 in LAC was examined by immunohistochemical assay using a tissue microarray procedure. A loss...

Journal: :Molecular pharmacology 2002
S Chiechio A Caricasole E Barletta M Storto M V Catania A Copani M Vertechy R Nicolai M Calvani D Melchiorri F Nicoletti

L-Acetylcarnitine (LAC, 100 mg/kg, s.c.), a drug commonly used for the treatment of painful neuropathies, substantially reduced mechanical allodynia in rats subjected to monolateral chronic constriction injury (CCI) of the sciatic nerve and also attenuated acute thermal pain in intact rats. In both cases, induction of analgesia required repeated injections of LAC, suggesting that the drug induc...

Journal: :AJNR. American journal of neuroradiology 2005
Xiaojuan Li Daniel B Vigneron Soonmee Cha Edward E Graves Forrest Crawford Susan M Chang Sarah J Nelson

BACKGROUND AND PURPOSE Gliomas are heterogeneous tumors with increased microvasculature, hypoxia, and necrosis. The purpose of this study was to examine the distribution and relationship of the MR-derived relative cerebral blood volume (rCBV), lactate (Lac), and mobile lipids (Lip), which have been proposed as markers for these phenomena of gliomas in vivo. METHODS Twenty-three patients with ...

2014
Jiapeng Fu Hui Qiao Dawei Li Lei Luo Ke Chen Qufu Wei

The study compared the biosensing properties of laccase biosensors based on carbon nanofibers (CNFs) and copper/carbon composite nanofibers (Cu/CNFs). The two kinds of nanofibers were prepared by electrospinning and carbonization under the same conditions. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Raman spectroscopy were employed to investigate the morphologies and structu...

Journal: :Journal of bacteriology 1970
J H Miller W S Reznikoff A E Silverstone K Ippen E R Signer J R Beckwith

Two classes of strains were studied in which the lac operon is transposed to a chromosomal site close to the tonB and trp loci. The two classes differ in the orientation of the lac region on the chromosome. In both types of strains, tonB mutants were selected in which deletions removing the tonB locus also caused a fusion of the lac and trp regions. The study of the properties of such fusion st...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
E Susan Slechta Kim L Bunny Elisabeth Kugelberg Eric Kofoid Dan I Andersson John R Roth

In a particular genetic system, selection stimulates reversion of a lac mutation and causes genome-wide mutagenesis (adaptive mutation). Selection allows rare plated cells with a duplication of the leaky lac allele to initiate clones within which further lac amplification improves growth rate. Growth and amplification add mutational targets to each clone and thereby increase the likelihood of r...

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